Statistical Inference for High-Dimensional Linear Regression with
Blockwise Missing Data
- URL: http://arxiv.org/abs/2106.03344v2
- Date: Wed, 28 Jun 2023 20:15:52 GMT
- Title: Statistical Inference for High-Dimensional Linear Regression with
Blockwise Missing Data
- Authors: Fei Xue, Rong Ma, Hongzhe Li
- Abstract summary: Blockwise missing data occurs when we integrate multisource or multimodality data where different sources or modalities contain complementary information.
We propose a computationally efficient estimator for the regression coefficient vector based on carefully constructed unbiased estimating equations.
Numerical studies and application analysis of the Alzheimer's Disease Neuroimaging Initiative data show that the proposed method performs better and benefits more from unsupervised samples than existing methods.
- Score: 13.48481978963297
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Blockwise missing data occurs frequently when we integrate multisource or
multimodality data where different sources or modalities contain complementary
information. In this paper, we consider a high-dimensional linear regression
model with blockwise missing covariates and a partially observed response
variable. Under this framework, we propose a computationally efficient
estimator for the regression coefficient vector based on carefully constructed
unbiased estimating equations and a blockwise imputation procedure, and obtain
its rate of convergence. Furthermore, building upon an innovative projected
estimating equation technique that intrinsically achieves bias-correction of
the initial estimator, we propose a nearly unbiased estimator for each
individual regression coefficient, which is asymptotically normally distributed
under mild conditions. Based on these debiased estimators, asymptotically valid
confidence intervals and statistical tests about each regression coefficient
are constructed. Numerical studies and application analysis of the Alzheimer's
Disease Neuroimaging Initiative data show that the proposed method performs
better and benefits more from unsupervised samples than existing methods.
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