Biocompatible surface functionalization architecture for a diamond
quantum sensor
- URL: http://arxiv.org/abs/2108.04843v1
- Date: Tue, 10 Aug 2021 18:01:35 GMT
- Title: Biocompatible surface functionalization architecture for a diamond
quantum sensor
- Authors: Mouzhe Xie, Xiaofei Yu, Lila V. H. Rodgers, Daohong Xu, Ignacio
Chi-Duran, Adrien Toros, Niels Quack, Nathalie P. de Leon, Peter C. Maurer
- Abstract summary: Diamond-based quantum sensing has enabled new class of biophysical sensors and diagnostic devices.
New approach combines quantum engineering with single-molecule biophysics to immobilize individual proteins and DNA molecules.
- Score: 0.0
- License: http://creativecommons.org/publicdomain/zero/1.0/
- Abstract: Quantum metrology enables some of the most precise measurements. In the life
sciences, diamond-based quantum sensing has enabled a new class of biophysical
sensors and diagnostic devices that are being investigated as a platform for
cancer screening and ultra-sensitive immunoassays. However, a broader
application in the life sciences based on nanoscale nuclear magnetic resonance
spectroscopy has been hampered by the need to interface highly sensitive
quantum bit (qubit) sensors with their biological targets. Here, we demonstrate
a new approach that combines quantum engineering with single-molecule
biophysics to immobilize individual proteins and DNA molecules on the surface
of a bulk diamond crystal that hosts coherent nitrogen vacancy qubit sensors.
Our thin (sub-5 nm) functionalization architecture provides precise control
over protein adsorption density and results in near-surface qubit coherence
approaching 100 {\mu}s. The developed architecture remains chemically stable
under physiological conditions for over five days, making our technique
compatible with most biophysical and biomedical applications.
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