Towards Launching AI Algorithms for Cellular Pathology into Clinical &
Pharmaceutical Orbits
- URL: http://arxiv.org/abs/2112.09496v1
- Date: Fri, 17 Dec 2021 13:05:16 GMT
- Title: Towards Launching AI Algorithms for Cellular Pathology into Clinical &
Pharmaceutical Orbits
- Abstract summary: Computational Pathology (CPath) is an emerging field concerned with the study of tissue pathology.
Recent deep learning based developments in CPath have successfully leveraged sheer volume of raw pixel data in histology images.
- Score: 1.7149364927872013
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Computational Pathology (CPath) is an emerging field concerned with the study
of tissue pathology via computational algorithms for the processing and
analysis of digitized high-resolution images of tissue slides. Recent deep
learning based developments in CPath have successfully leveraged sheer volume
of raw pixel data in histology images for predicting target parameters in the
domains of diagnostics, prognostics, treatment sensitivity and patient
stratification -- heralding the promise of a new data-driven AI era for both
histopathology and oncology. With data serving as the fuel and AI as the
engine, CPath algorithms are poised to be ready for takeoff and eventual launch
into clinical and pharmaceutical orbits. In this paper, we discuss CPath
limitations and associated challenges to enable the readers distinguish hope
from hype and provide directions for future research to overcome some of the
major challenges faced by this budding field to enable its launch into the two
orbits.
Related papers
- Explainable Artificial Intelligence (XAI) in Computational Pathology: Definitions, Taxonomy, and Recommendations [6.122990622242377]
Computational pathology (CompPath) is transforming medicine by leveraging artificial intelligence (AI) algorithms to support diagnosis, prognosis, and treatment prediction from gigapixel whole-slide images.<n>Clinical adoption is progressing, but is constrained by concerns about safety, accountability, and regulatory oversight in high-stakes clinical environments.
arXiv Detail & Related papers (2026-08-28T19:46:28Z) - A Semantically Enhanced Generative Foundation Model Improves Pathological Image Synthesis [82.01597026329158]
We introduce a Correlation-Regulated Alignment Framework for Tissue Synthesis (CRAFTS) for pathology-specific text-to-image synthesis.<n>CRAFTS incorporates a novel alignment mechanism that suppresses semantic drift to ensure biological accuracy.<n>This model generates diverse pathological images spanning 30 cancer types, with quality rigorously validated by objective metrics and pathologist evaluations.
arXiv Detail & Related papers (2025-12-15T10:22:43Z) - Multi-Class Segmentation of Aortic Branches and Zones in Computed Tomography Angiography: The AortaSeg24 Challenge [55.252714550918824]
AortaSeg24 MICCAI Challenge introduced the first dataset of 100 CTA volumes annotated for 23 clinically relevant aortic branches and zones.
This paper presents the challenge design, dataset details, evaluation metrics, and an in-depth analysis of the top-performing algorithms.
arXiv Detail & Related papers (2025-02-07T21:09:05Z) - A Survey on Computational Pathology Foundation Models: Datasets, Adaptation Strategies, and Evaluation Tasks [22.806228975730008]
Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histological data.
These models have demonstrated promise in automating complex pathology tasks such as segmentation, classification, and biomarker discovery.
However, the development of CPathFMs presents significant challenges, such as limited data accessibility, high variability across datasets, and lack of standardized evaluation benchmarks.
arXiv Detail & Related papers (2025-01-27T01:27:59Z) - PathoWAve: A Deep Learning-based Weight Averaging Method for Improving Domain Generalization in Histopathology Images [13.362177469092963]
We introduce Pathology Weight Averaging (PathoWAve) to tackle domain shift phenomenon in histopathology image analysis.
Our results on Camelyon17 WILDS dataset demonstrate PathoWAve's superiority over previous proposed methods.
arXiv Detail & Related papers (2024-06-21T23:25:44Z) - Now and Future of Artificial Intelligence-based Signet Ring Cell Diagnosis: A Survey [22.818887806396805]
Signet ring cells (SRCs) are associated with a high propensity for peripheral metastasis and poor prognosis.<n>This paper presents a comprehensive survey of AI-driven SRC analysis from 2008 through June 2025.
arXiv Detail & Related papers (2023-11-16T09:20:43Z) - Computational Pathology: A Survey Review and The Way Forward [35.29627164279813]
Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images.
Main objective for CPath is to develop infrastructure and vision of digital diagnostics as an assistive CAD system for clinical pathology.
arXiv Detail & Related papers (2023-04-11T20:28:33Z) - AI and Pathology: Steering Treatment and Predicting Outcomes [1.365100962983716]
We describe the rich set of application challenges related to tissue interpretation and survey AI methods.
We focus on a particular class of targeted human tissue analysis - histopathology - aimed at quantitative characterization of disease state, patient outcome prediction and treatment steering.
arXiv Detail & Related papers (2022-06-15T14:55:30Z) - Deep Learning for Computational Cytology: A Survey [12.08083533402352]
We introduce various deep learning methods, including fully supervised, weakly supervised, unsupervised, and transfer learning.
Then, we systematically summarize the public datasets, evaluation metrics, versatile cyto image analysis applications including classification, detection, segmentation, and other related tasks.
arXiv Detail & Related papers (2022-02-10T16:22:10Z) - REET: Robustness Evaluation and Enhancement Toolbox for Computational
Pathology [1.452875650827562]
We propose the first domain-specific Robustness Evaluation and Enhancement Toolbox (REET) for computational pathology applications.
REET provides a suite of algorithmic strategies for enabling robustness assessment of predictive models.
REET also enables efficient and robust training of deep learning pipelines in computational pathology.
arXiv Detail & Related papers (2022-01-28T18:23:55Z) - Unsupervised deep learning techniques for powdery mildew recognition
based on multispectral imaging [63.62764375279861]
This paper presents a deep learning approach to automatically recognize powdery mildew on cucumber leaves.
We focus on unsupervised deep learning techniques applied to multispectral imaging data.
We propose the use of autoencoder architectures to investigate two strategies for disease detection.
arXiv Detail & Related papers (2021-12-20T13:29:13Z) - Deep Algorithm Unrolling for Biomedical Imaging [99.73317152134028]
In this chapter, we review biomedical applications and breakthroughs via leveraging algorithm unrolling.
We trace the origin of algorithm unrolling and provide a comprehensive tutorial on how to unroll iterative algorithms into deep networks.
We conclude the chapter by discussing open challenges, and suggesting future research directions.
arXiv Detail & Related papers (2021-08-15T01:06:26Z) - Data-driven generation of plausible tissue geometries for realistic
photoacoustic image synthesis [53.65837038435433]
Photoacoustic tomography (PAT) has the potential to recover morphological and functional tissue properties.
We propose a novel approach to PAT data simulation, which we refer to as "learning to simulate"
We leverage the concept of Generative Adversarial Networks (GANs) trained on semantically annotated medical imaging data to generate plausible tissue geometries.
arXiv Detail & Related papers (2021-03-29T11:30:18Z) - An Uncertainty-Driven GCN Refinement Strategy for Organ Segmentation [53.425900196763756]
We propose a segmentation refinement method based on uncertainty analysis and graph convolutional networks.
We employ the uncertainty levels of the convolutional network in a particular input volume to formulate a semi-supervised graph learning problem.
We show that our method outperforms the state-of-the-art CRF refinement method by improving the dice score by 1% for the pancreas and 2% for spleen.
arXiv Detail & Related papers (2020-12-06T18:55:07Z) - Explaining Clinical Decision Support Systems in Medical Imaging using
Cycle-Consistent Activation Maximization [112.2628296775395]
Clinical decision support using deep neural networks has become a topic of steadily growing interest.
clinicians are often hesitant to adopt the technology because its underlying decision-making process is considered to be intransparent and difficult to comprehend.
We propose a novel decision explanation scheme based on CycleGAN activation which generates high-quality visualizations of classifier decisions even in smaller data sets.
arXiv Detail & Related papers (2020-10-09T14:39:27Z) - VerSe: A Vertebrae Labelling and Segmentation Benchmark for
Multi-detector CT Images [121.31355003451152]
Large Scale Vertebrae Challenge (VerSe) was organised in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2019 and 2020.
We present the the results of this evaluation and further investigate the performance-variation at vertebra-level, scan-level, and at different fields-of-view.
arXiv Detail & Related papers (2020-01-24T21:09:18Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.