Perceptual Features as Markers of Parkinson's Disease: The Issue of Clinical Interpretability

• URL: http://arxiv.org/abs/2203.10830v1
• Date: Mon, 21 Mar 2022 09:46:48 GMT
• Title: Perceptual Features as Markers of Parkinson's Disease: The Issue of Clinical Interpretability
• Authors: Jiri Mekyska, Zdenek Smekal, Zoltan Galaz, Zdenek Mzourek, Irena Rektorova, Marcos Faundez-Zanuy, Karmele Lopez-De-Ipina
• Abstract summary: Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) This paper provides large and robust insight into analysis of 5 Czech vowels of 84 PD patients.
• Score: 0.0
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by conventional clinical interpretable features (jitter, shimmer, harmonic-to-noise ratio, etc.). This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classification accuracy ACC = 92 %, sensitivity SEN = 93 %, specificity SPE = 92 %) and partial correlation with clinical scores like UPDRS (Unified Parkinson's disease rating scale), MMSE (Mini-mental state examination) or FOG (Freezing of gait questionnaire), where p < 0.0001.

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