Related papers: Tensorial tomographic differential phase-contrast microscopy

Tensorial tomographic differential phase-contrast microscopy

URL: http://arxiv.org/abs/2204.11397v1
Date: Mon, 25 Apr 2022 02:11:29 GMT
Title: Tensorial tomographic differential phase-contrast microscopy
Authors: Shiqi Xu, Xiang Dai, Xi Yang, Kevin C. Zhou, Kanghyun Kim, Vinayak Pathak, Carolyn Glass, Roarke Horstmeyer
Abstract summary: T2DPC extends differential phase-contrast microscopy, a quantitative phase imaging technique, to highlight the vectorial nature of light. We demonstrate accurate volumetric reconstructions of refractive index, birefringence, and orientation for various validation samples, and show that the reconstructed polarization structures of a biological specimen are predictive of pathology.
Score: 14.650158000199932
License: http://creativecommons.org/licenses/by/4.0/
Abstract: We report Tensorial Tomographic Differential Phase-Contrast microscopy (T2DPC), a quantitative label-free tomographic imaging method for simultaneous measurement of phase and anisotropy. T2DPC extends differential phase-contrast microscopy, a quantitative phase imaging technique, to highlight the vectorial nature of light. The method solves for permittivity tensor of anisotropic samples from intensity measurements acquired with a standard microscope equipped with an LED matrix, a circular polarizer, and a polarization-sensitive camera. We demonstrate accurate volumetric reconstructions of refractive index, birefringence, and orientation for various validation samples, and show that the reconstructed polarization structures of a biological specimen are predictive of pathology.

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