Phenomenological modeling of diverse and heterogeneous synaptic dynamics
at natural density
- URL: http://arxiv.org/abs/2212.05354v1
- Date: Sat, 10 Dec 2022 19:24:58 GMT
- Title: Phenomenological modeling of diverse and heterogeneous synaptic dynamics
at natural density
- Authors: Agnes Korcsak-Gorzo, Charl Linssen, Jasper Albers, Stefan Dasbach,
Renato Duarte, Susanne Kunkel, Abigail Morrison, Johanna Senk, Jonas
Stapmanns, Tom Tetzlaff, Markus Diesmann, Sacha J. van Albada
- Abstract summary: This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience.
It provides an introductory overview on how to account for empirical data in mathematical models, implement them in software, and perform simulations reflecting experiments.
- Score: 0.0
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: This chapter sheds light on the synaptic organization of the brain from the
perspective of computational neuroscience. It provides an introductory overview
on how to account for empirical data in mathematical models, implement them in
software, and perform simulations reflecting experiments. This path is
demonstrated with respect to four key aspects of synaptic signaling: the
connectivity of brain networks, synaptic transmission, synaptic plasticity, and
the heterogeneity across synapses. Each step and aspect of the modeling and
simulation workflow comes with its own challenges and pitfalls, which are
highlighted and addressed in detail.
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