Learning Absorption Rates in Glucose-Insulin Dynamics from Meal Covariates

• URL: http://arxiv.org/abs/2304.14300v1
• Date: Thu, 27 Apr 2023 16:03:41 GMT
• Title: Learning Absorption Rates in Glucose-Insulin Dynamics from Meal Covariates
• Authors: Ke Alexander Wang, Matthew E. Levine, Jiaxin Shi, Emily B. Fox
• Abstract summary: A meal's macronutritional content has nuanced effects on the absorption profile, which is difficult to model mechanistically. We use a neural network to predict an individual's glucose absorption rate.
• Score: 28.39179475412449
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Traditional models of glucose-insulin dynamics rely on heuristic parameterizations chosen to fit observations within a laboratory setting. However, these models cannot describe glucose dynamics in daily life. One source of failure is in their descriptions of glucose absorption rates after meal events. A meal's macronutritional content has nuanced effects on the absorption profile, which is difficult to model mechanistically. In this paper, we propose to learn the effects of macronutrition content from glucose-insulin data and meal covariates. Given macronutrition information and meal times, we use a neural network to predict an individual's glucose absorption rate. We use this neural rate function as the control function in a differential equation of glucose dynamics, enabling end-to-end training. On simulated data, our approach is able to closely approximate true absorption rates, resulting in better forecast than heuristic parameterizations, despite only observing glucose, insulin, and macronutritional information. Our work readily generalizes to meal events with higher-dimensional covariates, such as images, setting the stage for glucose dynamics models that are personalized to each individual's daily life.

Related papers

• Petri nets in modelling glucose regulating processes in the liver [0.0]
  We present a Petri net model of glycolysis and glucose synthesis in the liver. Our analysis shows that the model captures the interactions between different enzymes and substances. The model constitutes the first element of our long-time goal to create the whole body model of the glucose regulation in a healthy human and a person with diabetes.
  arXiv  Detail & Related papers  (2024-05-17T13:15:01Z)
• NutritionVerse-Direct: Exploring Deep Neural Networks for Multitask Nutrition Prediction from Food Images [63.314702537010355]
  Self-reporting methods are often inaccurate and suffer from substantial bias. Recent work has explored using computer vision prediction systems to predict nutritional information from food images. This paper aims to enhance the efficacy of dietary intake estimation by leveraging various neural network architectures.
  arXiv  Detail & Related papers  (2024-05-13T14:56:55Z)
• Toward Short-Term Glucose Prediction Solely Based on CGM Time Series [4.7066018521459725]
  TimeGlu is an end-to-end pipeline for short-term glucose prediction based on CGM time series data. It achieves state-of-the-art performance without the need for additional personal data from patients.
  arXiv  Detail & Related papers  (2024-04-18T06:02:12Z)
• Physical formula enhanced multi-task learning for pharmacokinetics prediction [54.13787789006417]
  A major challenge for AI-driven drug discovery is the scarcity of high-quality data. We develop a formula enhanced mul-ti-task learning (PEMAL) method that predicts four key parameters of pharmacokinetics simultaneously. Our experiments reveal that PEMAL significantly lowers the data demand, compared to typical Graph Neural Networks.
  arXiv  Detail & Related papers  (2024-04-16T07:42:55Z)
• Interpretable Mechanistic Representations for Meal-level Glycemic Control in the Wild [10.240619571788786]
  We propose a hybrid variational autoencoder to learn interpretable representations of CGM and meal data. Our method grounds the latent space to the inputs of a mechanistic differential equation, producing embeddings that reflect physiological quantities. Our embeddings produce clusters that are up to 4x better than naive, expert, black-box, and pure mechanistic features.
  arXiv  Detail & Related papers  (2023-12-06T08:36:23Z)
• NutritionVerse-Real: An Open Access Manually Collected 2D Food Scene Dataset for Dietary Intake Estimation [68.49526750115429]
  We introduce NutritionVerse-Real, an open access manually collected 2D food scene dataset for dietary intake estimation. The NutritionVerse-Real dataset was created by manually collecting images of food scenes in real life, measuring the weight of every ingredient and computing the associated dietary content of each dish.
  arXiv  Detail & Related papers  (2023-11-20T11:05:20Z)
• NutritionVerse: Empirical Study of Various Dietary Intake Estimation Approaches [60.97896788599621]
  Accurate dietary intake estimation is critical for informing policies and programs to support healthy eating. Recent work has focused on using computer vision and machine learning to automatically estimate dietary intake from food images. We introduce NutritionVerse- Synth, the first large-scale dataset of 84,984 synthetic 2D food images with associated dietary information. We also collect a real image dataset, NutritionVerse-Real, containing 889 images of 251 dishes to evaluate realism.
  arXiv  Detail & Related papers  (2023-09-14T13:29:41Z)
• Patterns Detection in Glucose Time Series by Domain Transformations and Deep Learning [0.0]
  We describe our research with the aim of predicting the future behavior of blood glucose levels, so that hypoglycemic events may be anticipated. We have tested our proposed method using real data from 4 different diabetes patients with promising results.
  arXiv  Detail & Related papers  (2023-03-30T09:08:31Z)
• Deep Personalized Glucose Level Forecasting Using Attention-based Recurrent Neural Networks [5.250950284616893]
  We study the problem of blood glucose forecasting and provide a deep personalized solution. We analyze the data and detect important patterns. We empirically show the efficacy of our model on a real dataset.
  arXiv  Detail & Related papers  (2021-06-02T01:36:53Z)
• Short Term Blood Glucose Prediction based on Continuous Glucose Monitoring Data [53.01543207478818]
  This study explores the use of Continuous Glucose Monitoring (CGM) data as input for digital decision support tools. We investigate how Recurrent Neural Networks (RNNs) can be used for Short Term Blood Glucose (STBG) prediction.
  arXiv  Detail & Related papers  (2020-02-06T16:39:44Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.