An Explainable Geometric-Weighted Graph Attention Network for Identifying Functional Networks Associated with Gait Impairment

• URL: http://arxiv.org/abs/2307.13108v1
• Date: Mon, 24 Jul 2023 19:57:21 GMT
• Title: An Explainable Geometric-Weighted Graph Attention Network for Identifying Functional Networks Associated with Gait Impairment
• Authors: Favour Nerrise (1), Qingyu Zhao (2), Kathleen L. Poston (3), Kilian M. Pohl (2), Ehsan Adeli (2) ((1) Department of Electrical Engineering, Stanford University, Stanford, CA, USA, (2) Dept. of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA, (3) Dept. of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA)
• Abstract summary: One of the hallmark symptoms of Parkinson's Disease (PD) is the progressive loss of postural reflexes. Identifying disruptions in brain function associated with gait impairment could be crucial in better understanding PD motor progression. We present an explainable, geometric, weighted-graph attention neural network (xGW-GAT) to identify functional networks predictive of the progression of gait difficulties.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: One of the hallmark symptoms of Parkinson's Disease (PD) is the progressive loss of postural reflexes, which eventually leads to gait difficulties and balance problems. Identifying disruptions in brain function associated with gait impairment could be crucial in better understanding PD motor progression, thus advancing the development of more effective and personalized therapeutics. In this work, we present an explainable, geometric, weighted-graph attention neural network (xGW-GAT) to identify functional networks predictive of the progression of gait difficulties in individuals with PD. xGW-GAT predicts the multi-class gait impairment on the MDS Unified PD Rating Scale (MDS-UPDRS). Our computational- and data-efficient model represents functional connectomes as symmetric positive definite (SPD) matrices on a Riemannian manifold to explicitly encode pairwise interactions of entire connectomes, based on which we learn an attention mask yielding individual- and group-level explainability. Applied to our resting-state functional MRI (rs-fMRI) dataset of individuals with PD, xGW-GAT identifies functional connectivity patterns associated with gait impairment in PD and offers interpretable explanations of functional subnetworks associated with motor impairment. Our model successfully outperforms several existing methods while simultaneously revealing clinically-relevant connectivity patterns. The source code is available at https://github.com/favour-nerrise/xGW-GAT .

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