Radical Pair Model for Magnetic Field Effects on NMDA Receptor Activity
- URL: http://arxiv.org/abs/2310.16725v2
- Date: Thu, 26 Oct 2023 05:21:39 GMT
- Title: Radical Pair Model for Magnetic Field Effects on NMDA Receptor Activity
- Authors: Parvathy S Nair, Hadi Zadeh-Haghighi and Christoph Simon
- Abstract summary: The N-methyl-D-aspartate receptor is a prominent player in brain development and functioning.
Various studies have shown that magnetic fields of varying strengths affect these receptors.
We propose that the radical pair mechanism, a quantum mechanical process, could explain some of these field effects.
- Score: 0.0
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: The N-methyl-D-aspartate receptor is a prominent player in brain development
and functioning. Perturbations to its functioning through external stimuli like
magnetic fields can potentially affect the brain in numerous ways. Various
studies have shown that magnetic fields of varying strengths affect these
receptors. We propose that the radical pair mechanism, a quantum mechanical
process, could explain some of these field effects. Radicals of the form
$[\mbox{RO}^\bullet \mbox{ Mg($\mbox{H}_2$O$)_n$}^{+\bullet}]$, where R is a
protein residue that can be Serine or Tyrosine, are considered for this study.
The variation in the singlet fractional yield of the radical pairs, as a
function of magnetic field strength, is calculated to understand how the
magnetic field affects the products of the radical pair reactions. Based on the
results, the radical pair mechanism is a likely candidate for explaining the
magnetic field effects observed on the receptor activity. The model predicts
changes in the behaviour of the system as magnetic field strength is varied and
also predicts certain isotope effects. The results further suggest that similar
effects on radical pairs could be a plausible explanation for various magnetic
field effects within the brain.
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