Radical pairs and superoxide amplification can explain magnetic field effects on planarian regeneration

• URL: http://arxiv.org/abs/2312.06597v1
• Date: Mon, 11 Dec 2023 18:31:01 GMT
• Title: Radical pairs and superoxide amplification can explain magnetic field effects on planarian regeneration
• Authors: Rishabh, Hadi Zadeh-Haghighi, Christoph Simon
• Abstract summary: Weak magnetic fields can modulate reactive oxygen species (ROS) concentration, affecting regeneration in planaria. We propose a radical pair mechanism based on a flavin-superoxide radical pair to explain the modulation of superoxide production. We also make empirical predictions concerning the hypomagnetic field effects on planarian regeneration.
• Score: 0.0
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Weak magnetic field exposure can affect many biological processes across a wide range of living organisms. Recently, it has been observed that weak magnetic fields can modulate reactive oxygen species (ROS) concentration, affecting regeneration in planaria. These effects show unusual nonlinear dependence on magnetic field strength, including a sign change. In another study by the same group, superoxide is identified as the particular ROS being modulated. We propose a radical pair mechanism based on a flavin-superoxide radical pair to explain the modulation of superoxide production and its effect on planarian regeneration. The results of our calculations favor a triplet-born radical pair. Our yield calculations can reproduce the observed magnetic field dependence, including the sign change. Moreover, to explain the size of the effect on ROS concentration, we suggest a simple amplification model inspired by known biochemical mechanisms and lay out the conditions for such a model to work. Further, we also make empirical predictions concerning the hypomagnetic field effects on planarian regeneration.

Related papers

• Radical Pair Mechanism and the Role of Chirality-Induced Spin Selectivity during Planaria Regeneration: Effect of Weak Magnetic Field on ROS levels [0.0]
  Planarian is an intriguing model system wherein the effect of electric and magnetic fields can be studied on various biochemical pathways. Recent experimental observations have demonstrated the non-trivial modulation of reactive oxygen species (ROS) levels by a weak magnetic field during planaria regeneration.
  arXiv  Detail & Related papers  (2024-01-09T12:58:08Z)
• Volumetric Reconstruction Resolves Off-Resonance Artifacts in Static and Dynamic PROPELLER MRI [76.60362295758596]
  Off-resonance artifacts in magnetic resonance imaging (MRI) are visual distortions that occur when the actual resonant frequencies of spins within the imaging volume differ from the expected frequencies used to encode spatial information. We propose to resolve these artifacts by lifting the 2D MRI reconstruction problem to 3D, introducing an additional "spectral" dimension to model this off-resonance.
  arXiv  Detail & Related papers  (2023-11-22T05:44:51Z)
• AI for Interpretable Chemistry: Predicting Radical Mechanistic Pathways via Contrastive Learning [45.379791270351184]
  RMechRP is a new deep learning-based reaction predictor system. We develop and train models using RMechDB, a public database of radical reactions. Our results demonstrate the effectiveness of RMechRP in providing accurate and interpretable predictions.
  arXiv  Detail & Related papers  (2023-11-02T09:47:27Z)
• Radical Pair Model for Magnetic Field Effects on NMDA Receptor Activity [0.0]
  The N-methyl-D-aspartate receptor is a prominent player in brain development and functioning. Various studies have shown that magnetic fields of varying strengths affect these receptors. We propose that the radical pair mechanism, a quantum mechanical process, could explain some of these field effects.
  arXiv  Detail & Related papers  (2023-10-25T15:53:31Z)
• Sensing of magnetic field effects in radical-pair reactions using a quantum sensor [50.591267188664666]
  Magnetic field effects (MFE) in certain chemical reactions have been well established in the last five decades. We employ elaborate and realistic models of radical-pairs, considering its coupling to the local spin environment and the sensor. For two model systems, we derive signals of MFE detectable even in the weak coupling regime between radical-pair and NV quantum sensor.
  arXiv  Detail & Related papers  (2022-09-28T12:56:15Z)
• Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis [0.0]
  Adult hippocampal neurogenesis and hippocampus-dependent cognition in mice adversely affected by hypomagnetic field exposure. Recent theoretic study suggests a mechanistic interpretation of this phenomenon in the framework of the Radical Pair Mechanism. We suggest that a model based on a radical triad and the assumption of a secondary radical scavenging reaction can, in principle, explain the phenomenon without unnatural assumptions.
  arXiv  Detail & Related papers  (2022-06-16T14:03:46Z)
• Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis [0.0]
  We propose a radical pair mechanism to explain the modulation of ROS production and the attenuation of adult hippocampal neurogenesis in a hypomagnetic field. Our model predicts hypomagnetic field effects on the triplet/singlet yield of comparable strength as the effects observed in experimental studies on adult hippocampal neurogenesis.
  arXiv  Detail & Related papers  (2021-10-25T03:19:22Z)
• Dispersive readout of molecular spin qudits [68.8204255655161]
  We study the physics of a magnetic molecule described by a "giant" spin with multiple $d > 2$ spin states. We derive an expression for the output modes in the dispersive regime of operation. We find that the measurement of the cavity transmission allows to uniquely determine the spin state of the qudits.
  arXiv  Detail & Related papers  (2021-09-29T18:00:09Z)
• Radical pairs may play a role in microtubule reorganization [0.0]
  It has been proposed that anesthetics selectively prevent consciousness and memory via acting on microtubules (MTs) We show that magnetic fields can modulate spin dynamics of naturally occurring radical pairs in MT. The findings of this work make a connection between microtubule-based and radical pair-based quantum theories of consciousness.
  arXiv  Detail & Related papers  (2021-09-28T21:23:12Z)
• Designer Magnetism in High Entropy Oxides [41.74498230885008]
  Disorder can have a dominating influence on correlated and quantum materials. In magnetic systems, spin and exchange disorder can provide access to quantum criticality, frustration, and spin dynamics. We show that high entropy oxides present an unexplored route to designing quantum materials.
  arXiv  Detail & Related papers  (2021-04-12T15:21:48Z)
• Effect of phonons on the electron spin resonance absorption spectrum [62.997667081978825]
  We model the effect of phonons and temperature on the electron spin resonance (ESR) signal in magnetically active systems. We find that the suppression of ESR signals is due to phonon broadening but not based on the common assumption of orbital quenching.
  arXiv  Detail & Related papers  (2020-04-22T01:13:07Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.