Pre- to Post-Contrast Breast MRI Synthesis for Enhanced Tumour Segmentation

• URL: http://arxiv.org/abs/2311.10879v3
• Date: Fri, 31 May 2024 16:15:01 GMT
• Title: Pre- to Post-Contrast Breast MRI Synthesis for Enhanced Tumour Segmentation
• Authors: Richard Osuala, Smriti Joshi, Apostolia Tsirikoglou, Lidia Garrucho, Walter H. L. Pinaya, Oliver Diaz, Karim Lekadir,
• Abstract summary: This study explores the feasibility of producing synthetic contrast enhancements by translating pre-contrast T1-weighted fat-saturated breast MRI to their corresponding first DCE-MRI sequence using a generative adversarial network (GAN) We assess the generated DCE-MRI data using quantitative image quality metrics and apply them to the downstream task of 3D breast tumour segmentation. Our results highlight the potential of post-contrast DCE-MRI synthesis in enhancing the robustness of breast tumour segmentation models via data augmentation.
• Score: 0.9722528000969453
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Despite its benefits for tumour detection and treatment, the administration of contrast agents in dynamic contrast-enhanced MRI (DCE-MRI) is associated with a range of issues, including their invasiveness, bioaccumulation, and a risk of nephrogenic systemic fibrosis. This study explores the feasibility of producing synthetic contrast enhancements by translating pre-contrast T1-weighted fat-saturated breast MRI to their corresponding first DCE-MRI sequence leveraging the capabilities of a generative adversarial network (GAN). Additionally, we introduce a Scaled Aggregate Measure (SAMe) designed for quantitatively evaluating the quality of synthetic data in a principled manner and serving as a basis for selecting the optimal generative model. We assess the generated DCE-MRI data using quantitative image quality metrics and apply them to the downstream task of 3D breast tumour segmentation. Our results highlight the potential of post-contrast DCE-MRI synthesis in enhancing the robustness of breast tumour segmentation models via data augmentation. Our code is available at https://github.com/RichardObi/pre_post_synthesis.

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