Impact of Large Language Model Assistance on Patients Reading Clinical Notes: A Mixed-Methods Study

• URL: http://arxiv.org/abs/2401.09637v1
• Date: Wed, 17 Jan 2024 23:14:52 GMT
• Title: Impact of Large Language Model Assistance on Patients Reading Clinical Notes: A Mixed-Methods Study
• Authors: Niklas Mannhardt, Elizabeth Bondi-Kelly, Barbara Lam, Chloe O'Connell, Mercy Asiedu, Hussein Mozannar, Monica Agrawal, Alejandro Buendia, Tatiana Urman, Irbaz B. Riaz, Catherine E. Ricciardi, Marzyeh Ghassemi, David Sontag
• Abstract summary: Complex medical concepts and jargon within clinical notes hinder patient comprehension and may lead to anxiety. We developed a patient-facing tool to simplify, extract information from, and add context to notes. Augmentations were evaluated for errors by clinicians, and we found misleading errors occur.
• Score: 47.61555826813361
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Patients derive numerous benefits from reading their clinical notes, including an increased sense of control over their health and improved understanding of their care plan. However, complex medical concepts and jargon within clinical notes hinder patient comprehension and may lead to anxiety. We developed a patient-facing tool to make clinical notes more readable, leveraging large language models (LLMs) to simplify, extract information from, and add context to notes. We prompt engineered GPT-4 to perform these augmentation tasks on real clinical notes donated by breast cancer survivors and synthetic notes generated by a clinician, a total of 12 notes with 3868 words. In June 2023, 200 female-identifying US-based participants were randomly assigned three clinical notes with varying levels of augmentations using our tool. Participants answered questions about each note, evaluating their understanding of follow-up actions and self-reported confidence. We found that augmentations were associated with a significant increase in action understanding score (0.63 $\pm$ 0.04 for select augmentations, compared to 0.54 $\pm$ 0.02 for the control) with p=0.002. In-depth interviews of self-identifying breast cancer patients (N=7) were also conducted via video conferencing. Augmentations, especially definitions, elicited positive responses among the seven participants, with some concerns about relying on LLMs. Augmentations were evaluated for errors by clinicians, and we found misleading errors occur, with errors more common in real donated notes than synthetic notes, illustrating the importance of carefully written clinical notes. Augmentations improve some but not all readability metrics. This work demonstrates the potential of LLMs to improve patients' experience with clinical notes at a lower burden to clinicians. However, having a human in the loop is important to correct potential model errors.

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