Pushing the Boundaries: Interferometric Mass Photometry at the Quantum Limit of Sensitivity

• URL: http://arxiv.org/abs/2410.19417v1
• Date: Fri, 25 Oct 2024 09:21:01 GMT
• Title: Pushing the Boundaries: Interferometric Mass Photometry at the Quantum Limit of Sensitivity
• Authors: Fabian Müller, Emre Köse, Alfred J. Meixner, Erik Schäffer, Daniel Braun,
• Abstract summary: In comparison to the conventional confocal interferometric scattering (iSCAT) approach, our setup adds a second arm to form a Michelson interferometer. We evaluate the quantum Cram'er-Rao bound (QCRB) for different quantum states, including single-mode coherent states, multi-frequency coherent states, and phase-averaged coherent states.
• Score: 0.7864304771129751
• License:
• Abstract: We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering (iSCAT) approach, our setup adds a second arm to form a Michelson interferometer that allows us to tune a relative phase. We evaluate the quantum Cram\'er-Rao bound (QCRB) for different quantum states, including single-mode coherent states, multi-frequency coherent states, and phase-averaged coherent states. Our results show that the proposed setup can achieve the QCRB of sensitivity and outperform iSCAT for all considered quantum states for mass and phase estimation of a particle.

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