Structured Extraction of Real World Medical Knowledge using LLMs for Summarization and Search

• URL: http://arxiv.org/abs/2412.15256v1
• Date: Mon, 16 Dec 2024 02:57:00 GMT
• Title: Structured Extraction of Real World Medical Knowledge using LLMs for Summarization and Search
• Authors: Edward Kim, Manil Shrestha, Richard Foty, Tom DeLay, Vicki Seyfert-Margolis,
• Abstract summary: We propose creating patient knowledge graphs using large model extraction techniques. Our method maps to existing hierarchies (SHMe, SNOMED-CT RxNORM, HPO) to ground extracted entities. We describe our construction of patient-specific knowledge graphs and symptom-based patient searches.
• Score: 1.3453658538563749
• License:
• Abstract: Creation and curation of knowledge graphs can accelerate disease discovery and analysis in real-world data. While disease ontologies aid in biological data annotation, codified categories (SNOMED-CT, ICD10, CPT) may not capture patient condition nuances or rare diseases. Multiple disease definitions across data sources complicate ontology mapping and disease clustering. We propose creating patient knowledge graphs using large language model extraction techniques, allowing data extraction via natural language rather than rigid ontological hierarchies. Our method maps to existing ontologies (MeSH, SNOMED-CT, RxNORM, HPO) to ground extracted entities. Using a large ambulatory care EHR database with 33.6M patients, we demonstrate our method through the patient search for Dravet syndrome, which received ICD10 recognition in October 2020. We describe our construction of patient-specific knowledge graphs and symptom-based patient searches. Using confirmed Dravet syndrome ICD10 codes as ground truth, we employ LLM-based entity extraction to characterize patients in grounded ontologies. We then apply this method to identify Beta-propeller protein-associated neurodegeneration (BPAN) patients, demonstrating real-world discovery where no ground truth exists.

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