Physics-Guided Multi-View Graph Neural Network for Schizophrenia Classification via Structural-Functional Coupling

• URL: http://arxiv.org/abs/2505.15135v1
• Date: Wed, 21 May 2025 05:41:48 GMT
• Title: Physics-Guided Multi-View Graph Neural Network for Schizophrenia Classification via Structural-Functional Coupling
• Authors: Badhan Mazumder, Ayush Kanyal, Lei Wu, Vince D. Calhoun, Dong Hye Ye,
• Abstract summary: Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ)<n>Traditional approaches might rely solely on functional data availability and cognitive comprehension of schizophrenia (SZ)
• Score: 16.781078467240985
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ). Traditional approaches might rely solely on SC due to limited functional data availability, hindering comprehension of cognitive and behavioral impairments in individuals with SZ by neglecting the intricate SC-FC interrelationship. To tackle the challenge, we propose a novel physics-guided deep learning framework that leverages a neural oscillation model to describe the dynamics of a collection of interconnected neural oscillators, which operate via nerve fibers dispersed across the brain's structure. Our proposed framework utilizes SC to simultaneously generate FC by learning SC-FC coupling from a system dynamics perspective. Additionally, it employs a novel multi-view graph neural network (GNN) with a joint loss to perform correlation-based SC-FC fusion and classification of individuals with SZ. Experiments conducted on a clinical dataset exhibited improved performance, demonstrating the robustness of our proposed approach.

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