One Brain, Omni Modalities: Towards Unified Non-Invasive Brain Decoding with Large Language Models

• URL: http://arxiv.org/abs/2602.21522v1
• Date: Wed, 25 Feb 2026 03:24:54 GMT
• Title: One Brain, Omni Modalities: Towards Unified Non-Invasive Brain Decoding with Large Language Models
• Authors: Changli Tang, Shurui Li, Junliang Wang, Qinfan Xiao, Zhonghao Zhai, Lei Bai, Yu Qiao, Bowen Zhou, Wen Wu, Yuanning Li, Chao Zhang,
• Abstract summary: We introduce textbfNOBEL, a textbfneuro-textbfomni-modal textbfbrain-textbfencoding textbflarge language model (LLM)<n>Our architecture integrates a unified encoder for EEG and MEG with a novel dual-path strategy for fMRI, aligning non-invasive brain signals and external sensory stimuli into a shared token space.
• Score: 42.83819917665563
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Deciphering brain function through non-invasive recordings requires synthesizing complementary high-frequency electromagnetic (EEG/MEG) and low-frequency metabolic (fMRI) signals. However, despite their shared neural origins, extreme discrepancies have traditionally confined these modalities to isolated analysis pipelines, hindering a holistic interpretation of brain activity. To bridge this fragmentation, we introduce \textbf{NOBEL}, a \textbf{n}euro-\textbf{o}mni-modal \textbf{b}rain-\textbf{e}ncoding \textbf{l}arge language model (LLM) that unifies these heterogeneous signals within the LLM's semantic embedding space. Our architecture integrates a unified encoder for EEG and MEG with a novel dual-path strategy for fMRI, aligning non-invasive brain signals and external sensory stimuli into a shared token space, then leverages an LLM as a universal backbone. Extensive evaluations demonstrate that NOBEL serves as a robust generalist across standard single-modal tasks. We also show that the synergistic fusion of electromagnetic and metabolic signals yields higher decoding accuracy than unimodal baselines, validating the complementary nature of multiple neural modalities. Furthermore, NOBEL exhibits strong capabilities in stimulus-aware decoding, effectively interpreting visual semantics from multi-subject fMRI data on the NSD and HAD datasets while uniquely leveraging direct stimulus inputs to verify causal links between sensory signals and neural responses. NOBEL thus takes a step towards unifying non-invasive brain decoding, demonstrating the promising potential of omni-modal brain understanding.

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