GazeXPErT: An Expert Eye-tracking Dataset for Interpretable and Explainable AI in Oncologic FDG-PET/CT Scans

• URL: http://arxiv.org/abs/2603.00162v1
• Date: Thu, 26 Feb 2026 04:39:15 GMT
• Title: GazeXPErT: An Expert Eye-tracking Dataset for Interpretable and Explainable AI in Oncologic FDG-PET/CT Scans
• Authors: Joy T Wu, Daniel Beckmann, Sarah Miller, Alexander Lee, Elizabeth Theng, Stephan Altmayer, Ken Chang, David Kersting, Tomoaki Otani, Brittany Z Dashevsky, Hye Lim Park, Matteo Novello, Kip Guja, Curtis Langlotz, Ismini Lourentzou, Daniel Gruhl, Benjamin Risse, Guido A Davidzon,
• Abstract summary: We present GazeXPErT, a 4D eye-tracking dataset capturing expert search patterns during tumor detection and measurement.<n>From 3,948 minutes of raw 60Hz eye-tracking data, 9,030 unique gaze-to-lesion trajectories were extracted, synchronized with PET/CT image slices, and rendered in COCO-style format for machine learning applications.
• Score: 32.135469601806754
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: [18F]FDG-PET/CT is a cornerstone imaging modality for tumor staging and treatment response assessment across many cancer types, yet expert reader shortages necessitate more efficient diagnostic aids. While standalone AI models for automatic lesion segmentation exist, clinical translation remains hindered by concerns about interpretability, explainability, reliability, and workflow integration. We present GazeXPErT, a 4D eye-tracking dataset capturing expert search patterns during tumor detection and measurement on 346 FDG-PET/CT scans. Each study was read by a trainee and a board-certified nuclear medicine or radiology specialist using an eye-tracking-enabled annotation platform that simulates routine clinical reads. From 3,948 minutes of raw 60Hz eye-tracking data, 9,030 unique gaze-to-lesion trajectories were extracted, synchronized with PET/CT image slices, and rendered in COCO-style format for multiple machine learning applications. Baseline validation experiments demonstrate that a 3D nnUNet tumor segmentation model achieved superior performance when incorporating expert gaze patterns versus without (DICE score 0.6819 versus 0.6008), and that vision transformers trained on sequential gaze and PET/CT images can improve dynamic lesion localization (74.95% predicted gaze point closer to tumor) and expert intention prediction (Accuracy 67.53% and AUROC 0.747). GazeXPErT is a valuable resource designed to explore multiple machine learning problems beyond these baseline experiments, which include and are not limited to, visual grounding or causal reasoning, clinically explainable feature augmentation, human-computer interaction, human intention prediction or understanding, and expert gaze-rewarded modeling approaches to AI in oncologic FDG-PET/CT imaging.

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