PRIME-CVD: A Parametrically Rendered Informatics Medical Environment for Education in Cardiovascular Risk Modelling

• URL: http://arxiv.org/abs/2603.19299v1
• Date: Wed, 11 Mar 2026 05:57:22 GMT
• Title: PRIME-CVD: A Parametrically Rendered Informatics Medical Environment for Education in Cardiovascular Risk Modelling
• Abstract summary: PRIME-CVD is a medical environment designed explicitly for medical education.<n>It comprises two openly accessible synthetic data assets representing a cohort of 50,000 adults undergoing primary prevention for cardiovascular disease.<n>Data Asset 1 provides a clean, analysis-ready cohort suitable for exploratory analysis, stratification, and survival modelling, while Data Asset 2 restructures the same cohort into a relational, EMR-style database with realistic structural and lexical heterogeneity.<n>Because all individuals and events are generated de novo, PRIME-CVD preserves realistic subgroup imbalance and risk gradients while ensuring negligible disclosure risk.
• Score: 0.93496537653413
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: In recent years, progress in medical informatics and machine learning has been accelerated by the availability of openly accessible benchmark datasets. However, patient-level electronic medical record (EMR) data are rarely available for teaching or methodological development due to privacy, governance, and re-identification risks. This has limited reproducibility, transparency, and hands-on training in cardiovascular risk modelling. Here we introduce PRIME-CVD, a parametrically rendered informatics medical environment designed explicitly for medical education. PRIME-CVD comprises two openly accessible synthetic data assets representing a cohort of 50,000 adults undergoing primary prevention for cardiovascular disease. The datasets are generated entirely from a user-specified causal directed acyclic graph parameterised using publicly available Australian population statistics and published epidemiologic effect estimates, rather than from patient-level EMR data or trained generative models. Data Asset 1 provides a clean, analysis-ready cohort suitable for exploratory analysis, stratification, and survival modelling, while Data Asset 2 restructures the same cohort into a relational, EMR-style database with realistic structural and lexical heterogeneity. Together, these assets enable instruction in data cleaning, harmonisation, causal reasoning, and policy-relevant risk modelling without exposing sensitive information. Because all individuals and events are generated de novo, PRIME-CVD preserves realistic subgroup imbalance and risk gradients while ensuring negligible disclosure risk. PRIME-CVD is released under a Creative Commons Attribution 4.0 licence to support reproducible research and scalable medical education.

Related papers

• BiPETE: A Bi-Positional Embedding Transformer Encoder for Risk Assessment of Alcohol and Substance Use Disorder with Electronic Health Records [3.305393384521011]
  We propose a Bi-Positional Embedding Transformer or BiPETE for single-disease prediction.<n>BiPETE is trained on EHR data from two mental health cohorts-depressive disorder and post-traumatic stress disorder (PTSD)-to predict the risk of alcohol and substance use disorders.
  arXiv  Detail & Related papers  (2025-11-07T06:01:25Z)
• Integrating Genomics into Multimodal EHR Foundation Models [56.31910745104141]
  This paper introduces an innovative EHR foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality.<n>The framework aims to learn complex relationships between clinical data and genetic predispositions.<n>This approach is pivotal for unlocking new insights into disease prediction, proactive health management, risk stratification, and personalized treatment strategies.
  arXiv  Detail & Related papers  (2025-10-24T15:56:40Z)
• Adaptable Cardiovascular Disease Risk Prediction from Heterogeneous Data using Large Language Models [70.64969663547703]
  AdaCVD is an adaptable CVD risk prediction framework built on large language models extensively fine-tuned on over half a million participants from the UK Biobank.<n>It addresses key clinical challenges across three dimensions: it flexibly incorporates comprehensive yet variable patient information; it seamlessly integrates both structured data and unstructured text; and it rapidly adapts to new patient populations using minimal additional data.
  arXiv  Detail & Related papers  (2025-05-30T14:42:02Z)
• FedCVD: The First Real-World Federated Learning Benchmark on Cardiovascular Disease Data [52.55123685248105]
  Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide, highlighting the critical need for early diagnosis and treatment. Machine learning (ML) methods can help diagnose CVDs early, but their performance relies on access to substantial data with high quality. This paper presents the first real-world FL benchmark for cardiovascular disease detection, named FedCVD.
  arXiv  Detail & Related papers  (2024-10-28T02:24:01Z)
• MedDiffusion: Boosting Health Risk Prediction via Diffusion-based Data Augmentation [58.93221876843639]
  This paper introduces a novel, end-to-end diffusion-based risk prediction model, named MedDiffusion. It enhances risk prediction performance by creating synthetic patient data during training to enlarge sample space. It discerns hidden relationships between patient visits using a step-wise attention mechanism, enabling the model to automatically retain the most vital information for generating high-quality data.
  arXiv  Detail & Related papers  (2023-10-04T01:36:30Z)
• Integrated Convolutional and Recurrent Neural Networks for Health Risk Prediction using Patient Journey Data with Many Missing Values [9.418011774179794]
  This paper proposes a novel end-to-end approach to modeling EHR patient journey data with Integrated Convolutional and Recurrent Neural Networks. Our model can capture both long- and short-term temporal patterns within each patient journey and effectively handle the high degree of missingness in EHR data without any imputation data generation.
  arXiv  Detail & Related papers  (2022-11-11T07:36:18Z)
• Bootstrapping Your Own Positive Sample: Contrastive Learning With Electronic Health Record Data [62.29031007761901]
  This paper proposes a novel contrastive regularized clinical classification model. We introduce two unique positive sampling strategies specifically tailored for EHR data. Our framework yields highly competitive experimental results in predicting the mortality risk on real-world COVID-19 EHR data.
  arXiv  Detail & Related papers  (2021-04-07T06:02:04Z)
• UNITE: Uncertainty-based Health Risk Prediction Leveraging Multi-sourced Data [81.00385374948125]
  We present UNcertaInTy-based hEalth risk prediction (UNITE) model. UNITE provides accurate disease risk prediction and uncertainty estimation leveraging multi-sourced health data. We evaluate UNITE on real-world disease risk prediction tasks: nonalcoholic fatty liver disease (NASH) and Alzheimer's disease (AD) UNITE achieves up to 0.841 in F1 score for AD detection, up to 0.609 in PR-AUC for NASH detection, and outperforms various state-of-the-art baselines by up to $19%$ over the best baseline.
  arXiv  Detail & Related papers  (2020-10-22T02:28:11Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.