A Two-Stage Multi-Modal MRI Framework for Lifespan Brain Age Prediction

• URL: http://arxiv.org/abs/2604.16655v1
• Date: Fri, 17 Apr 2026 19:20:54 GMT
• Title: A Two-Stage Multi-Modal MRI Framework for Lifespan Brain Age Prediction
• Abstract summary: We develop a multi-modal brain age framework to characterize the integrated evolution of brain morphology and white matter organization.<n>This design enables a unified and lifespan-spanning assessment of brain maturity across diverse developmental periods.
• Score: 9.233005519397365
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture the coordinated macro- and microstructural changes that unfold across the human lifespan. To address these limitations, we developed a multi-modal brain age framework to characterize the integrated evolution of brain morphology and white matter organization. Our model adopts a two-stage architecture, where modalities are processed independently and integrated via late fusion in both stages: first to classify each subject into one of six developmental stages, and then to estimate age within the predicted stage. This design enables a unified and lifespan-spanning assessment of brain maturity across diverse developmental periods.

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