From Patches to Patients: A study of the tile-to-slide performance transferability in Digital Pathology

• URL: http://arxiv.org/abs/2606.10778v1
• Date: Tue, 09 Jun 2026 12:33:14 GMT
• Title: From Patches to Patients: A study of the tile-to-slide performance transferability in Digital Pathology
• Abstract summary: We investigate whether efficient tile-level linear probing can serve as a reliable proxy for slide-level performance.<n>We benchmark 19 state-of-the-art FMs on 42 slide-level and 16 tile-level tasks.
• Score: 5.356949046416353
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Foundation Models (FMs) have recently redefined the state-of-the-art in histopathology by providing robust representations for whole-slide image (WSI) analysis. However, selecting the optimal foundation model (FM) for a specific clinical cohort currently requires multiple preprocessing steps, followed by computationally expensive feature extraction and the training of a Multiple Instance Learning (MIL) aggregator for every model. In this work, we investigate whether efficient tile-level linear probing can serve as a reliable proxy for slide-level performance, reducing the need to run full slide-level pipelines for every candidate encoder. We benchmark 19 state-of-the-art FMs on 42 slide-level and 16 tile-level tasks, comparing tile probing metrics against slide-level outcomes using ABMIL and Mean Pooling aggregations. We observe a high correlation between tile and slide performance across varying task difficulties, indicating that encoder representation quality is the primary determinant of WSI success. Sensitivity analyses show that transferability is stable across models and is more influenced by cohort sizes and numbers of tiles per slide than by average task difficulty. We also measure the agreement in best performing models between tile and slide-level tasks, showing tile benchmarks reliably shortlist strong candidates. Overall, our study indicates that tile-level benchmarking provides an efficient and practical first step for narrowing down candidate models, while slide-level evaluation remains essential for final validation on clinical tasks.

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