Deep ROC Analysis and AUC as Balanced Average Accuracy to Improve Model
Selection, Understanding and Interpretation
- URL: http://arxiv.org/abs/2103.11357v1
- Date: Sun, 21 Mar 2021 10:27:35 GMT
- Title: Deep ROC Analysis and AUC as Balanced Average Accuracy to Improve Model
Selection, Understanding and Interpretation
- Authors: Andr\'e M. Carrington, Douglas G. Manuel, Paul W. Fieguth, Tim Ramsay,
Venet Osmani, Bernhard Wernly, Carol Bennett, Steven Hawken, Matthew McInnes,
Olivia Magwood, Yusuf Sheikh, Andreas Holzinger
- Abstract summary: Optimal performance is critical for decision-making tasks from medicine to autonomous driving.
Measures such as accuracy, sensitivity or the F1 score are measures at a single threshold that reflect an individual single probability or predicted risk.
We propose a method in between, deep ROC analysis, that examines groups of probabilities or predicted risks for more insightful analysis.
- Score: 4.7096631717710045
- License: http://creativecommons.org/licenses/by-nc-sa/4.0/
- Abstract: Optimal performance is critical for decision-making tasks from medicine to
autonomous driving, however common performance measures may be too general or
too specific. For binary classifiers, diagnostic tests or prognosis at a
timepoint, measures such as the area under the receiver operating
characteristic curve, or the area under the precision recall curve, are too
general because they include unrealistic decision thresholds. On the other
hand, measures such as accuracy, sensitivity or the F1 score are measures at a
single threshold that reflect an individual single probability or predicted
risk, rather than a range of individuals or risk. We propose a method in
between, deep ROC analysis, that examines groups of probabilities or predicted
risks for more insightful analysis. We translate esoteric measures into
familiar terms: AUC and the normalized concordant partial AUC are balanced
average accuracy (a new finding); the normalized partial AUC is average
sensitivity; and the normalized horizontal partial AUC is average specificity.
Along with post-test measures, we provide a method that can improve model
selection in some cases and provide interpretation and assurance for patients
in each risk group. We demonstrate deep ROC analysis in two case studies and
provide a toolkit in Python.
Related papers
- PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification [2.6911061523689415]
The current "golden standard" relies on manual BI-RADS scoring by clinicians, often leading to unnecessary biopsies and a significant mental health burden on patients and their families.
We introduce PersonalizedUS, an interpretable machine learning system that leverages recent advances in conformal prediction to provide precise and personalized risk estimates.
Concrete clinical benefits include up to a 65% reduction in requested biopsies among BI-RADS 4a and 4b lesions, with minimal to no missed cancer cases.
arXiv Detail & Related papers (2024-08-28T00:47:55Z) - Improving Bias Correction Standards by Quantifying its Effects on Treatment Outcomes [54.18828236350544]
Propensity score matching (PSM) addresses selection biases by selecting comparable populations for analysis.
Different matching methods can produce significantly different Average Treatment Effects (ATE) for the same task, even when meeting all validation criteria.
To address this issue, we introduce a novel metric, A2A, to reduce the number of valid matches.
arXiv Detail & Related papers (2024-07-20T12:42:24Z) - Structural-Based Uncertainty in Deep Learning Across Anatomical Scales: Analysis in White Matter Lesion Segmentation [8.64414399041931]
Uncertainty quantification (UQ) is an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation.
We develop measures for quantifying uncertainty at lesion and patient scales, derived from structural prediction discrepancies.
The results from a multi-centric MRI dataset of 444 patients demonstrate that our proposed measures more effectively capture model errors at the lesion and patient scales.
arXiv Detail & Related papers (2023-11-15T13:04:57Z) - Diagnosis Uncertain Models For Medical Risk Prediction [80.07192791931533]
We consider a patient risk model which has access to vital signs, lab values, and prior history but does not have access to a patient's diagnosis.
We show that such all-cause' risk models have good generalization across diagnoses but have a predictable failure mode.
We propose a fix for this problem by explicitly modeling the uncertainty in risk prediction coming from uncertainty in patient diagnoses.
arXiv Detail & Related papers (2023-06-29T23:36:04Z) - Uncertainty estimations methods for a deep learning model to aid in
clinical decision-making -- a clinician's perspective [0.0]
There are several deep learning-inspired uncertainty estimation techniques, but few are implemented on medical datasets.
We compared dropout variational inference (DO), test-time augmentation (TTA), conformal predictions, and single deterministic methods for estimating uncertainty.
It may be important to evaluate multiple estimations techniques before incorporating a model into clinical practice.
arXiv Detail & Related papers (2022-10-02T17:54:54Z) - Mitigating multiple descents: A model-agnostic framework for risk
monotonization [84.6382406922369]
We develop a general framework for risk monotonization based on cross-validation.
We propose two data-driven methodologies, namely zero- and one-step, that are akin to bagging and boosting.
arXiv Detail & Related papers (2022-05-25T17:41:40Z) - Robust and Agnostic Learning of Conditional Distributional Treatment
Effects [62.44901952244514]
The conditional average treatment effect (CATE) is the best point prediction of individual causal effects.
In aggregate analyses, this is usually addressed by measuring distributional treatment effect (DTE)
We provide a new robust and model-agnostic methodology for learning the conditional DTE (CDTE) for a wide class of problems.
arXiv Detail & Related papers (2022-05-23T17:40:31Z) - A New Approach for Interpretability and Reliability in Clinical Risk
Prediction: Acute Coronary Syndrome Scenario [0.33927193323747895]
We intend to create a new risk assessment methodology that combines the best characteristics of both risk score and machine learning models.
The proposed approach achieved testing results identical to the standard LR, but offers superior interpretability and personalization.
The reliability estimation of individual predictions presented a great correlation with the misclassifications rate.
arXiv Detail & Related papers (2021-10-15T19:33:46Z) - Increasing the efficiency of randomized trial estimates via linear
adjustment for a prognostic score [59.75318183140857]
Estimating causal effects from randomized experiments is central to clinical research.
Most methods for historical borrowing achieve reductions in variance by sacrificing strict type-I error rate control.
arXiv Detail & Related papers (2020-12-17T21:10:10Z) - UNITE: Uncertainty-based Health Risk Prediction Leveraging Multi-sourced
Data [81.00385374948125]
We present UNcertaInTy-based hEalth risk prediction (UNITE) model.
UNITE provides accurate disease risk prediction and uncertainty estimation leveraging multi-sourced health data.
We evaluate UNITE on real-world disease risk prediction tasks: nonalcoholic fatty liver disease (NASH) and Alzheimer's disease (AD)
UNITE achieves up to 0.841 in F1 score for AD detection, up to 0.609 in PR-AUC for NASH detection, and outperforms various state-of-the-art baselines by up to $19%$ over the best baseline.
arXiv Detail & Related papers (2020-10-22T02:28:11Z) - Optimal Best-Arm Identification Methods for Tail-Risk Measures [9.128264779870538]
Conditional value-at-risk (CVaR) and value-at-risk (VaR) are popular tail-risk measures in finance and insurance industries.
We identify the smallest CVaR, VaR, or sum of CVaR and mean from amongst finitely that has smallest CVaR, VaR, or sum of CVaR and mean.
arXiv Detail & Related papers (2020-08-17T20:23:24Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.