A Diffeomorphic Aging Model for Adult Human Brain from Cross-Sectional Data

• URL: http://arxiv.org/abs/2106.14516v1
• Date: Mon, 28 Jun 2021 10:04:05 GMT
• Title: A Diffeomorphic Aging Model for Adult Human Brain from Cross-Sectional Data
• Authors: Alphin J Thottupattu and Jayanthi Sivaswamy and Venkateswaran P.Krishnan
• Abstract summary: We propose a method to develop an aging model for a given population by using images from different subjects at different time points. The proposed model is successfully validated on two public cross-sectional datasets.
• Score: 3.2188961353850187
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Normative aging trends of the brain can serve as an important reference in the assessment of neurological structural disorders. Such models are typically developed from longitudinal brain image data -- follow-up data of the same subject over different time points. In practice, obtaining such longitudinal data is difficult. We propose a method to develop an aging model for a given population, in the absence of longitudinal data, by using images from different subjects at different time points, the so-called cross-sectional data. We define an aging model as a diffeomorphic deformation on a structural template derived from the data and propose a method that develops topology preserving aging model close to natural aging. The proposed model is successfully validated on two public cross-sectional datasets which provide templates constructed from different sets of subjects at different age points.

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