Infant Brain Age Classification: 2D CNN Outperforms 3D CNN in Small
Dataset
- URL: http://arxiv.org/abs/2112.13811v1
- Date: Mon, 27 Dec 2021 18:02:48 GMT
- Title: Infant Brain Age Classification: 2D CNN Outperforms 3D CNN in Small
Dataset
- Authors: Mahdieh Shabanian, Markus Wenzel, John P. DeVincenzo
- Abstract summary: Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond myelination.
With no standardized criteria, visual estimation of the structural maturity of the brain from MRI before three years of age remains dominated by inter-observer and intra-observer variability.
We explore the general feasibility to tackle this task, and the utility of different approaches, including two- and three-dimensional convolutional neural networks (CNN)
In the best performing approach, we achieved an accuracy of 0.90 [95% CI:0.86-0.94] using a 2D CNN on a central axial thick slab.
- Score: 0.14063138455565613
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Determining if the brain is developing normally is a key component of
pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI)
of infants demonstrates a specific pattern of development beyond simply
myelination. While radiologists have used myelination patterns, brain
morphology and size characteristics to determine age-adequate brain maturity,
this requires years of experience in pediatric neuroradiology. With no
standardized criteria, visual estimation of the structural maturity of the
brain from MRI before three years of age remains dominated by inter-observer
and intra-observer variability. A more objective estimation of brain
developmental age could help physicians identify many neurodevelopmental
conditions and diseases earlier and more reliably. Such data, however, is
naturally hard to obtain, and the observer ground truth not much of a gold
standard due to subjectivity of assessment. In this light, we explore the
general feasibility to tackle this task, and the utility of different
approaches, including two- and three-dimensional convolutional neural networks
(CNN) that were trained on a fusion of T1-weighted, T2-weighted, and proton
density (PD) weighted sequences from 84 individual subjects divided into four
age groups from birth to 3 years of age. In the best performing approach, we
achieved an accuracy of 0.90 [95% CI:0.86-0.94] using a 2D CNN on a central
axial thick slab. We discuss the comparison to 3D networks and show how the
performance compares to the use of only one sequence (T1w). In conclusion,
despite the theoretical superiority of 3D CNN approaches, in limited-data
situations, such approaches are inferior to simpler architectures. The code can
be found in https://github.com/shabanian2018/Age_MRI-Classification
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