Self-Supervised Learning for Physiologically-Based Pharmacokinetic Modeling in Dynamic PET

• URL: http://arxiv.org/abs/2305.10569v1
• Date: Wed, 17 May 2023 21:08:02 GMT
• Title: Self-Supervised Learning for Physiologically-Based Pharmacokinetic Modeling in Dynamic PET
• Authors: Francesca De Benetti, Walter Simson, Magdalini Paschali, Hasan Sari, Axel Romiger, Kuangyu Shi, Nassir Navab and Thomas Wendler
• Abstract summary: Voxel-wise physiologically-based modeling of the time activity curves (TAC) can provide relevant diagnostic information for clinical workflow. This work introduces a self-supervisedPET loss formulation to enforce the similarity between the measured TAC and those generated with the learned kinetic parameters. To the best of our knowledge, this is the first self-supervised network that allows elvox-wise computation of kinetic parameters consistent with a non-linear kinetic model.
• Score: 36.28565007063204
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Dynamic positron emission tomography imaging (dPET) provides temporally resolved images of a tracer enabling a quantitative measure of physiological processes. Voxel-wise physiologically-based pharmacokinetic (PBPK) modeling of the time activity curves (TAC) can provide relevant diagnostic information for clinical workflow. Conventional fitting strategies for TACs are slow and ignore the spatial relation between neighboring voxels. We train a spatio-temporal UNet to estimate the kinetic parameters given TAC from F-18-fluorodeoxyglucose (FDG) dPET. This work introduces a self-supervised loss formulation to enforce the similarity between the measured TAC and those generated with the learned kinetic parameters. Our method provides quantitatively comparable results at organ-level to the significantly slower conventional approaches, while generating pixel-wise parametric images which are consistent with expected physiology. To the best of our knowledge, this is the first self-supervised network that allows voxel-wise computation of kinetic parameters consistent with a non-linear kinetic model. The code will become publicly available upon acceptance.

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