Developing a Novel Holistic, Personalized Dementia Risk Prediction Model via Integration of Machine Learning and Network Systems Biology Approaches

• URL: http://arxiv.org/abs/2311.09229v2
• Date: Wed, 10 Jan 2024 21:08:59 GMT
• Title: Developing a Novel Holistic, Personalized Dementia Risk Prediction Model via Integration of Machine Learning and Network Systems Biology Approaches
• Authors: Srilekha Mamidala
• Abstract summary: The proposed framework utilizes a novel holistic approach to dementia risk prediction. It is the first to incorporate various sources of environmental pollution and lifestyle factor data with network systems biology-based genetic data. The developed model successfully employs holistic computational dementia risk prediction for clinical use.
• Score: 0.0
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: The prevalence of dementia has increased over time as global life expectancy improves and populations age. An individual's risk of developing dementia is influenced by various genetic, lifestyle, and environmental factors, among others. Predicting dementia risk may enable individuals to employ mitigation strategies or lifestyle changes to delay dementia onset. Current computational approaches to dementia prediction only return risk upon narrow categories of variables and do not account for interactions between different risk variables. The proposed framework utilizes a novel holistic approach to dementia risk prediction and is the first to incorporate various sources of tabular environmental pollution and lifestyle factor data with network systems biology-based genetic data. LightGBM gradient boosting was employed to ensure validity of included factors. This approach successfully models interactions between variables through an original weighted integration method coined Sysable. Multiple machine learning models trained the algorithm to reduce reliance on a single model. The developed approach surpassed all existing dementia risk prediction approaches, with a sensitivity of 85%, specificity of 99%, geometric accuracy of 92%, and AUROC of 91.7%. A transfer learning model was implemented as well. De-biasing algorithms were run on the model via the AI Fairness 360 Library. Effects of demographic disparities on dementia prevalence were analyzed to potentially highlight areas in need and promote equitable and accessible care. The resulting model was additionally integrated into a user-friendly app providing holistic predictions and personalized risk mitigation strategies. The developed model successfully employs holistic computational dementia risk prediction for clinical use.

Related papers

• Seeing Unseen: Discover Novel Biomedical Concepts via Geometry-Constrained Probabilistic Modeling [53.7117640028211]
  We present a geometry-constrained probabilistic modeling treatment to resolve the identified issues. We incorporate a suite of critical geometric properties to impose proper constraints on the layout of constructed embedding space. A spectral graph-theoretic method is devised to estimate the number of potential novel classes.
  arXiv  Detail & Related papers  (2024-03-02T00:56:05Z)
• MedDiffusion: Boosting Health Risk Prediction via Diffusion-based Data Augmentation [58.93221876843639]
  This paper introduces a novel, end-to-end diffusion-based risk prediction model, named MedDiffusion. It enhances risk prediction performance by creating synthetic patient data during training to enlarge sample space. It discerns hidden relationships between patient visits using a step-wise attention mechanism, enabling the model to automatically retain the most vital information for generating high-quality data.
  arXiv  Detail & Related papers  (2023-10-04T01:36:30Z)
• Neural Fine-Gray: Monotonic neural networks for competing risks [0.0]
  Time-to-event modelling, known as survival analysis, differs from standard regression as it addresses censoring in patients who do not experience the event of interest. This paper leverages constrained monotonic neural networks to model each competing survival distribution. The effectiveness of the solution is demonstrated on one synthetic and three medical datasets.
  arXiv  Detail & Related papers  (2023-05-11T10:27:59Z)
• Deep Learning of Semi-Competing Risk Data via a New Neural Expectation-Maximization Algorithm [5.253100011321437]
  Our motivation comes from the Boston Lung Cancer Study, which investigates how risk factors influence a patient's disease trajectory. We propose a novel neural expectation-maximization algorithm to bridge the gap between classical statistical approaches and machine learning.
  arXiv  Detail & Related papers  (2022-12-22T20:38:57Z)
• Data-Centric Epidemic Forecasting: A Survey [56.99209141838794]
  This survey delves into various data-driven methodological and practical advancements. We enumerate the large number of epidemiological datasets and novel data streams that are relevant to epidemic forecasting. We also discuss experiences and challenges that arise in real-world deployment of these forecasting systems.
  arXiv  Detail & Related papers  (2022-07-19T16:15:11Z)
• A New Approach for Interpretability and Reliability in Clinical Risk Prediction: Acute Coronary Syndrome Scenario [0.33927193323747895]
  We intend to create a new risk assessment methodology that combines the best characteristics of both risk score and machine learning models. The proposed approach achieved testing results identical to the standard LR, but offers superior interpretability and personalization. The reliability estimation of individual predictions presented a great correlation with the misclassifications rate.
  arXiv  Detail & Related papers  (2021-10-15T19:33:46Z)
• Bootstrapping Your Own Positive Sample: Contrastive Learning With Electronic Health Record Data [62.29031007761901]
  This paper proposes a novel contrastive regularized clinical classification model. We introduce two unique positive sampling strategies specifically tailored for EHR data. Our framework yields highly competitive experimental results in predicting the mortality risk on real-world COVID-19 EHR data.
  arXiv  Detail & Related papers  (2021-04-07T06:02:04Z)
• An explainable Transformer-based deep learning model for the prediction of incident heart failure [22.513476932615845]
  We developed a novel Transformer deep-learning model for prediction of incident heart failure involving 100,071 patients. The model achieved 0.93 and 0.93 area under the receiver operator curve and 0.69 and 0.70 area under the precision-recall curve. The importance of contextualised medical information was revealed in sensitivity analyses.
  arXiv  Detail & Related papers  (2021-01-27T12:45:15Z)
• UNITE: Uncertainty-based Health Risk Prediction Leveraging Multi-sourced Data [81.00385374948125]
  We present UNcertaInTy-based hEalth risk prediction (UNITE) model. UNITE provides accurate disease risk prediction and uncertainty estimation leveraging multi-sourced health data. We evaluate UNITE on real-world disease risk prediction tasks: nonalcoholic fatty liver disease (NASH) and Alzheimer's disease (AD) UNITE achieves up to 0.841 in F1 score for AD detection, up to 0.609 in PR-AUC for NASH detection, and outperforms various state-of-the-art baselines by up to $19%$ over the best baseline.
  arXiv  Detail & Related papers  (2020-10-22T02:28:11Z)
• Neuro-symbolic Neurodegenerative Disease Modeling as Probabilistic Programmed Deep Kernels [93.58854458951431]
  We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches. We run evaluations on the problem of Alzheimer's disease prediction, yielding results that surpass deep learning.
  arXiv  Detail & Related papers  (2020-09-16T15:16:03Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.