Scientific Large Language Models: A Survey on Biological & Chemical Domains
- URL: http://arxiv.org/abs/2401.14656v2
- Date: Tue, 23 Jul 2024 13:56:42 GMT
- Title: Scientific Large Language Models: A Survey on Biological & Chemical Domains
- Authors: Qiang Zhang, Keyang Ding, Tianwen Lyv, Xinda Wang, Qingyu Yin, Yiwen Zhang, Jing Yu, Yuhao Wang, Xiaotong Li, Zhuoyi Xiang, Kehua Feng, Xiang Zhuang, Zeyuan Wang, Ming Qin, Mengyao Zhang, Jinlu Zhang, Jiyu Cui, Tao Huang, Pengju Yan, Renjun Xu, Hongyang Chen, Xiaolin Li, Xiaohui Fan, Huabin Xing, Huajun Chen,
- Abstract summary: Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension.
The application of LLMs extends beyond conventional linguistic boundaries, encompassing specialized linguistic systems developed within various scientific disciplines.
As a burgeoning area in the community of AI for Science, scientific LLMs warrant comprehensive exploration.
- Score: 47.97810890521825
- License: http://creativecommons.org/licenses/by-nc-nd/4.0/
- Abstract: Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing a significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional linguistic boundaries, encompassing specialized linguistic systems developed within various scientific disciplines. This growing interest has led to the advent of scientific LLMs, a novel subclass specifically engineered for facilitating scientific discovery. As a burgeoning area in the community of AI for Science, scientific LLMs warrant comprehensive exploration. However, a systematic and up-to-date survey introducing them is currently lacking. In this paper, we endeavor to methodically delineate the concept of "scientific language", whilst providing a thorough review of the latest advancements in scientific LLMs. Given the expansive realm of scientific disciplines, our analysis adopts a focused lens, concentrating on the biological and chemical domains. This includes an in-depth examination of LLMs for textual knowledge, small molecules, macromolecular proteins, genomic sequences, and their combinations, analyzing them in terms of model architectures, capabilities, datasets, and evaluation. Finally, we critically examine the prevailing challenges and point out promising research directions along with the advances of LLMs. By offering a comprehensive overview of technical developments in this field, this survey aspires to be an invaluable resource for researchers navigating the intricate landscape of scientific LLMs.
Related papers
- MolCap-Arena: A Comprehensive Captioning Benchmark on Language-Enhanced Molecular Property Prediction [44.27112553103388]
We present Molecule Caption Arena: the first comprehensive benchmark of large language models (LLMs)augmented molecular property prediction.
We evaluate over twenty LLMs, including both general-purpose and domain-specific molecule captioners, across diverse prediction tasks.
Our findings confirm the ability of LLM-extracted knowledge to enhance state-of-the-art molecular representations.
arXiv Detail & Related papers (2024-11-01T17:03:16Z) - A Comprehensive Survey of Scientific Large Language Models and Their Applications in Scientific Discovery [68.48094108571432]
Large language models (LLMs) have revolutionized the way text and other modalities of data are handled.
We aim to provide a more holistic view of the research landscape by unveiling cross-field and cross-modal connections between scientific LLMs.
arXiv Detail & Related papers (2024-06-16T08:03:24Z) - SciKnowEval: Evaluating Multi-level Scientific Knowledge of Large Language Models [35.98892300665275]
We introduce the SciKnowEval benchmark, a framework that evaluates large language models (LLMs) across five progressive levels of scientific knowledge.
These levels aim to assess the breadth and depth of scientific knowledge in LLMs, including memory, comprehension, reasoning, discernment, and application.
We benchmark 26 advanced open-source and proprietary LLMs using zero-shot and few-shot prompting strategies.
arXiv Detail & Related papers (2024-06-13T13:27:52Z) - LLM and Simulation as Bilevel Optimizers: A New Paradigm to Advance Physical Scientific Discovery [141.39722070734737]
We propose to enhance the knowledge-driven, abstract reasoning abilities of Large Language Models with the computational strength of simulations.
We introduce Scientific Generative Agent (SGA), a bilevel optimization framework.
We conduct experiments to demonstrate our framework's efficacy in law discovery and molecular design.
arXiv Detail & Related papers (2024-05-16T03:04:10Z) - Mapping the Increasing Use of LLMs in Scientific Papers [99.67983375899719]
We conduct the first systematic, large-scale analysis across 950,965 papers published between January 2020 and February 2024 on the arXiv, bioRxiv, and Nature portfolio journals.
Our findings reveal a steady increase in LLM usage, with the largest and fastest growth observed in Computer Science papers.
arXiv Detail & Related papers (2024-04-01T17:45:15Z) - Uni-SMART: Universal Science Multimodal Analysis and Research Transformer [22.90687836544612]
We present bfUni-text, an innovative model designed for in-depth understanding of scientific literature.
Uni-text demonstrates superior performance over other text-focused LLMs.
Our exploration extends to practical applications, including patent infringement detection and nuanced analysis of charts.
arXiv Detail & Related papers (2024-03-15T13:43:47Z) - SciInstruct: a Self-Reflective Instruction Annotated Dataset for Training Scientific Language Models [57.96527452844273]
We introduce SciInstruct, a suite of scientific instructions for training scientific language models capable of college-level scientific reasoning.
We curated a diverse and high-quality dataset encompassing physics, chemistry, math, and formal proofs.
To verify the effectiveness of SciInstruct, we fine-tuned different language models with SciInstruct, i.e., ChatGLM3 (6B and 32B), Llama3-8B-Instruct, and Mistral-7B: MetaMath.
arXiv Detail & Related papers (2024-01-15T20:22:21Z) - An Interdisciplinary Outlook on Large Language Models for Scientific
Research [3.4108358650013573]
We describe the capabilities and constraints of Large Language Models (LLMs) within disparate academic disciplines, aiming to delineate their strengths and limitations with precision.
We examine how LLMs augment scientific inquiry, offering concrete examples such as accelerating literature review by summarizing vast numbers of publications.
We articulate the challenges LLMs face, including their reliance on extensive and sometimes biased datasets, and the potential ethical dilemmas stemming from their use.
arXiv Detail & Related papers (2023-11-03T19:41:09Z) - A Comprehensive Overview of Large Language Models [68.22178313875618]
Large Language Models (LLMs) have recently demonstrated remarkable capabilities in natural language processing tasks.
This article provides an overview of the existing literature on a broad range of LLM-related concepts.
arXiv Detail & Related papers (2023-07-12T20:01:52Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.