Improving Medical Reasoning through Retrieval and Self-Reflection with Retrieval-Augmented Large Language Models

• URL: http://arxiv.org/abs/2401.15269v3
• Date: Tue, 18 Jun 2024 02:10:15 GMT
• Title: Improving Medical Reasoning through Retrieval and Self-Reflection with Retrieval-Augmented Large Language Models
• Authors: Minbyul Jeong, Jiwoong Sohn, Mujeen Sung, Jaewoo Kang,
• Abstract summary: Self-BioRAG is a framework reliable for biomedical text that specializes in generating explanations, retrieving domain-specific documents, and self-reflecting generated responses. We utilize 84k filtered biomedical instruction sets to train Self-BioRAG that can assess its generated explanations with customized reflective tokens.
• Score: 18.984165679347026
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that still cannot be handled with the encoded knowledge of LLMs, various retrieval-augmented generation (RAG) methods have been developed by searching documents from the knowledge corpus and appending them unconditionally or selectively to the input of LLMs for generation. However, when applying existing methods to different domain-specific problems, poor generalization becomes apparent, leading to fetching incorrect documents or making inaccurate judgments. In this paper, we introduce Self-BioRAG, a framework reliable for biomedical text that specializes in generating explanations, retrieving domain-specific documents, and self-reflecting generated responses. We utilize 84k filtered biomedical instruction sets to train Self-BioRAG that can assess its generated explanations with customized reflective tokens. Our work proves that domain-specific components, such as a retriever, domain-related document corpus, and instruction sets are necessary for adhering to domain-related instructions. Using three major medical question-answering benchmark datasets, experimental results of Self-BioRAG demonstrate significant performance gains by achieving a 7.2% absolute improvement on average over the state-of-the-art open-foundation model with a parameter size of 7B or less. Overall, we analyze that Self-BioRAG finds the clues in the question, retrieves relevant documents if needed, and understands how to answer with information from retrieved documents and encoded knowledge as a medical expert does. We release our data and code for training our framework components and model weights (7B and 13B) to enhance capabilities in biomedical and clinical domains.

Related papers

• NeuroSym-BioCAT: Leveraging Neuro-Symbolic Methods for Biomedical Scholarly Document Categorization and Question Answering [0.14999444543328289]
  We introduce a novel approach that integrates an optimized topic modelling framework, OVB-LDA, with the BI-POP CMA-ES optimization technique for enhanced scholarly document abstract categorization. We employ the distilled MiniLM model, fine-tuned on domain-specific data, for high-precision answer extraction.
  arXiv  Detail & Related papers  (2024-10-29T14:45:12Z)
• AutoMIR: Effective Zero-Shot Medical Information Retrieval without Relevance Labels [19.90354530235266]
  We introduce a novel approach called Self-Learning Hypothetical Document Embeddings (SL-HyDE) to tackle this issue. SL-HyDE leverages large language models (LLMs) as generators to generate hypothetical documents based on a given query. We present the Chinese Medical Information Retrieval Benchmark (CMIRB), a comprehensive evaluation framework grounded in real-world medical scenarios.
  arXiv  Detail & Related papers  (2024-10-26T02:53:20Z)
• GMAI-MMBench: A Comprehensive Multimodal Evaluation Benchmark Towards General Medical AI [67.09501109871351]
  Large Vision-Language Models (LVLMs) are capable of handling diverse data types such as imaging, text, and physiological signals. GMAI-MMBench is the most comprehensive general medical AI benchmark with well-categorized data structure and multi-perceptual granularity to date. It is constructed from 284 datasets across 38 medical image modalities, 18 clinical-related tasks, 18 departments, and 4 perceptual granularities in a Visual Question Answering (VQA) format.
  arXiv  Detail & Related papers  (2024-08-06T17:59:21Z)
• SeRTS: Self-Rewarding Tree Search for Biomedical Retrieval-Augmented Generation [50.26966969163348]
  Large Language Models (LLMs) have shown great potential in the biomedical domain with the advancement of retrieval-augmented generation (RAG) Existing retrieval-augmented approaches face challenges in addressing diverse queries and documents, particularly for medical knowledge queries. We propose Self-Rewarding Tree Search (SeRTS) based on Monte Carlo Tree Search (MCTS) and a self-rewarding paradigm.
  arXiv  Detail & Related papers  (2024-06-17T06:48:31Z)
• BiomedRAG: A Retrieval Augmented Large Language Model for Biomedicine [19.861178160437827]
  Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains. textscBiomedRAG attains superior performance across 5 biomedical NLP tasks. textscBiomedRAG outperforms other triple extraction systems with micro-F1 scores of 81.42 and 88.83 on GIT and ChemProt corpora, respectively.
  arXiv  Detail & Related papers  (2024-05-01T12:01:39Z)
• Graph-Based Retriever Captures the Long Tail of Biomedical Knowledge [2.2814097119704058]
  Large language models (LLMs) are transforming the way information is retrieved with vast amounts of knowledge being summarized and presented. LLMs are prone to highlight the most frequently seen pieces of information from the training set and to neglect the rare ones. We introduce a novel information-retrieval method that leverages a knowledge graph to downsample these clusters and mitigate the information overload problem.
  arXiv  Detail & Related papers  (2024-02-19T18:31:11Z)
• Diversifying Knowledge Enhancement of Biomedical Language Models using Adapter Modules and Knowledge Graphs [54.223394825528665]
  We develop an approach that uses lightweight adapter modules to inject structured biomedical knowledge into pre-trained language models. We use two large KGs, the biomedical knowledge system UMLS and the novel biochemical OntoChem, with two prominent biomedical PLMs, PubMedBERT and BioLinkBERT. We show that our methodology leads to performance improvements in several instances while keeping requirements in computing power low.
  arXiv  Detail & Related papers  (2023-12-21T14:26:57Z)
• Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflection [74.51523859064802]
  We introduce a new framework called Self-Reflective Retrieval-Augmented Generation (Self-RAG) Self-RAG enhances an LM's quality and factuality through retrieval and self-reflection. It significantly outperforms state-of-the-art LLMs and retrieval-augmented models on a diverse set of tasks.
  arXiv  Detail & Related papers  (2023-10-17T18:18:32Z)
• EBOCA: Evidences for BiOmedical Concepts Association Ontology [55.41644538483948]
  This paper proposes EBOCA, an ontology that describes (i) biomedical domain concepts and associations between them, and (ii) evidences supporting these associations. Test data coming from a subset of DISNET and automatic association extractions from texts has been transformed to create a Knowledge Graph that can be used in real scenarios.
  arXiv  Detail & Related papers  (2022-08-01T18:47:03Z)
• Recent Advances in Automated Question Answering In Biomedical Domain [0.06922389632860546]
  In the past few decades there has been a proliferation of acquisition of knowledge and consequently there has been an exponential growth in new scientific articles in the field of biomedicine. It has become difficult to keep track of all the information in the domain, even for domain experts. With the improvements in commercial search engines, users can type in their queries and get a small set of documents most relevant for answering their query. This has necessitated the development of efficient QA systems which aim to find exact and precise answers to user provided natural language questions.
  arXiv  Detail & Related papers  (2021-11-10T20:51:29Z)
• Self-supervised Answer Retrieval on Clinical Notes [68.87777592015402]
  We introduce CAPR, a rule-based self-supervision objective for training Transformer language models for domain-specific passage matching. We apply our objective in four Transformer-based architectures: Contextual Document Vectors, Bi-, Poly- and Cross-encoders. We report that CAPR outperforms strong baselines in the retrieval of domain-specific passages and effectively generalizes across rule-based and human-labeled passages.
  arXiv  Detail & Related papers  (2021-08-02T10:42:52Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.