Related papers: Early prediction of onset of sepsis in Clinical Setting

Early prediction of onset of sepsis in Clinical Setting

URL: http://arxiv.org/abs/2402.03486v1
Date: Mon, 5 Feb 2024 19:58:40 GMT
Title: Early prediction of onset of sepsis in Clinical Setting
Authors: Fahim Mohammad, Lakshmi Arunachalam, Samanway Sadhu, Boudewijn Aasman, Shweta Garg, Adil Ahmed, Silvie Colman, Meena Arunachalam, Sudhir Kulkarni, Parsa Mirhaji
Abstract summary: A supervised learning approach was adopted, wherein an XGBoost model was trained utilizing 80% of the train dataset. The model was validated on prospective data that was entirely unseen during the training phase. The model achieved a normalized utility score of 0.494 on test data and 0.378 on prospective data at threshold 0.3.
Score: 0.8471078314535754
License: http://creativecommons.org/licenses/by/4.0/
Abstract: This study proposes the use of Machine Learning models to predict the early onset of sepsis using deidentified clinical data from Montefiore Medical Center in Bronx, NY, USA. A supervised learning approach was adopted, wherein an XGBoost model was trained utilizing 80\% of the train dataset, encompassing 107 features (including the original and derived features). Subsequently, the model was evaluated on the remaining 20\% of the test data. The model was validated on prospective data that was entirely unseen during the training phase. To assess the model's performance at the individual patient level and timeliness of the prediction, a normalized utility score was employed, a widely recognized scoring methodology for sepsis detection, as outlined in the PhysioNet Sepsis Challenge paper. Metrics such as F1 Score, Sensitivity, Specificity, and Flag Rate were also devised. The model achieved a normalized utility score of 0.494 on test data and 0.378 on prospective data at threshold 0.3. The F1 scores were 80.8\% and 67.1\% respectively for the test data and the prospective data for the same threshold, highlighting its potential to be integrated into clinical decision-making processes effectively. These results bear testament to the model's robust predictive capabilities and its potential to substantially impact clinical decision-making processes.

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