Zero-Shot Image Denoising for High-Resolution Electron Microscopy

• URL: http://arxiv.org/abs/2406.14264v1
• Date: Thu, 20 Jun 2024 12:40:18 GMT
• Title: Zero-Shot Image Denoising for High-Resolution Electron Microscopy
• Authors: Xuanyu Tian, Zhuoya Dong, Xiyue Lin, Yue Gao, Hongjiang Wei, Yanhang Ma, Jingyi Yu, Yuyao Zhang,
• Abstract summary: High-resolution electron microscopy (HREM) imaging technique is a powerful tool for directly visualizing a broad range of materials in real-space. It faces challenges in denoising due to ultra-low signal-to-noise ratio (SNR) and scarce data availability. We propose Noise2SR, a zero-shot self-supervised learning (ZS-SSL) denoising framework for HREM.
• Score: 28.34992348748098
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: High-resolution electron microscopy (HREM) imaging technique is a powerful tool for directly visualizing a broad range of materials in real-space. However, it faces challenges in denoising due to ultra-low signal-to-noise ratio (SNR) and scarce data availability. In this work, we propose Noise2SR, a zero-shot self-supervised learning (ZS-SSL) denoising framework for HREM. Within our framework, we propose a super-resolution (SR) based self-supervised training strategy, incorporating the Random Sub-sampler module. The Random Sub-sampler is designed to generate approximate infinite noisy pairs from a single noisy image, serving as an effective data augmentation in zero-shot denoising. Noise2SR trains the network with paired noisy images of different resolutions, which is conducted via SR strategy. The SR-based training facilitates the network adopting more pixels for supervision, and the random sub-sampling helps compel the network to learn continuous signals enhancing the robustness. Meanwhile, we mitigate the uncertainty caused by random-sampling by adopting minimum mean squared error (MMSE) estimation for the denoised results. With the distinctive integration of training strategy and proposed designs, Noise2SR can achieve superior denoising performance using a single noisy HREM image. We evaluate the performance of Noise2SR in both simulated and real HREM denoising tasks. It outperforms state-of-the-art ZS-SSL methods and achieves comparable denoising performance with supervised methods. The success of Noise2SR suggests its potential for improving the SNR of images in material imaging domains.

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