Ensemble Modeling of Multiple Physical Indicators to Dynamically Phenotype Autism Spectrum Disorder

• URL: http://arxiv.org/abs/2408.13255v1
• Date: Fri, 23 Aug 2024 17:55:58 GMT
• Title: Ensemble Modeling of Multiple Physical Indicators to Dynamically Phenotype Autism Spectrum Disorder
• Authors: Marie Huynh, Aaron Kline, Saimourya Surabhi, Kaitlyn Dunlap, Onur Cezmi Mutlu, Mohammadmahdi Honarmand, Parnian Azizian, Peter Washington, Dennis P. Wall,
• Abstract summary: We provide a dataset for training computer vision models to detect Autism Spectrum Disorder (ASD)-related phenotypic markers. We trained individual LSTM-based models using eye gaze, head positions, and facial landmarks as input features, achieving test AUCs of 86%, 67%, and 78%.
• Score: 3.6630139570443996
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Early detection of autism, a neurodevelopmental disorder marked by social communication challenges, is crucial for timely intervention. Recent advancements have utilized naturalistic home videos captured via the mobile application GuessWhat. Through interactive games played between children and their guardians, GuessWhat has amassed over 3,000 structured videos from 382 children, both diagnosed with and without Autism Spectrum Disorder (ASD). This collection provides a robust dataset for training computer vision models to detect ASD-related phenotypic markers, including variations in emotional expression, eye contact, and head movements. We have developed a protocol to curate high-quality videos from this dataset, forming a comprehensive training set. Utilizing this set, we trained individual LSTM-based models using eye gaze, head positions, and facial landmarks as input features, achieving test AUCs of 86%, 67%, and 78%, respectively. To boost diagnostic accuracy, we applied late fusion techniques to create ensemble models, improving the overall AUC to 90%. This approach also yielded more equitable results across different genders and age groups. Our methodology offers a significant step forward in the early detection of ASD by potentially reducing the reliance on subjective assessments and making early identification more accessibly and equitable.

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