MMLNB: Multi-Modal Learning for Neuroblastoma Subtyping Classification Assisted with Textual Description Generation

• URL: http://arxiv.org/abs/2503.12927v2
• Date: Wed, 19 Mar 2025 09:27:16 GMT
• Title: MMLNB: Multi-Modal Learning for Neuroblastoma Subtyping Classification Assisted with Textual Description Generation
• Authors: Huangwei Chen, Yifei Chen, Zhenyu Yan, Mingyang Ding, Chenlei Li, Zhu Zhu, Feiwei Qin,
• Abstract summary: We introduce MMLNB, a multi-modal learning model that integrates pathological images with generated textual descriptions to improve classification accuracy and interpretability.<n>This research creates a scalable AI-driven framework for digital pathology, enhancing reliability and interpretability in Neuroblastoma subtyping classification.
• Score: 1.8947479010393964
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective evaluations that are time-consuming and inconsistent. To address these challenges, we introduce MMLNB, a multi-modal learning (MML) model that integrates pathological images with generated textual descriptions to improve classification accuracy and interpretability. The approach follows a two-stage process. First, we fine-tune a Vision-Language Model (VLM) to enhance pathology-aware text generation. Second, the fine-tuned VLM generates textual descriptions, using a dual-branch architecture to independently extract visual and textual features. These features are fused via Progressive Robust Multi-Modal Fusion (PRMF) Block for stable training. Experimental results show that the MMLNB model is more accurate than the single modal model. Ablation studies demonstrate the importance of multi-modal fusion, fine-tuning, and the PRMF mechanism. This research creates a scalable AI-driven framework for digital pathology, enhancing reliability and interpretability in NB subtyping classification. Our source code is available at https://github.com/HovChen/MMLNB.

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