Multi-Resolution Pathology-Language Pre-training Model with Text-Guided Visual Representation

• URL: http://arxiv.org/abs/2504.18856v1
• Date: Sat, 26 Apr 2025 08:44:04 GMT
• Title: Multi-Resolution Pathology-Language Pre-training Model with Text-Guided Visual Representation
• Abstract summary: We propose a novel multi-resolution paradigm leveraging Whole Slide Images (WSIs) to extract histology patches at multiple resolutions.<n>We introduce visual-textual alignment at multiple resolutions as well as cross-resolution alignment to establish more effective text-guided visual representations.<n>Our model aims to capture a broader range of information, supported by novel loss functions, enriches feature representation, improves discriminative ability, and enhances generalization across different resolutions.
• Score: 35.50570174431677
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be sufficient for tasks like cancer subtype classification, tissue phenotyping, and survival analysis due to the limited level of detail that a single-resolution image can provide. Addressing this, we propose a novel multi-resolution paradigm leveraging Whole Slide Images (WSIs) to extract histology patches at multiple resolutions and generate corresponding textual descriptions through advanced CPath VLM. We introduce visual-textual alignment at multiple resolutions as well as cross-resolution alignment to establish more effective text-guided visual representations. Cross-resolution alignment using a multimodal encoder enhances the model's ability to capture context from multiple resolutions in histology images. Our model aims to capture a broader range of information, supported by novel loss functions, enriches feature representation, improves discriminative ability, and enhances generalization across different resolutions. Pre-trained on a comprehensive TCGA dataset with 34 million image-language pairs at various resolutions, our fine-tuned model outperforms state-of-the-art (SOTA) counterparts across multiple datasets and tasks, demonstrating its effectiveness in CPath. The code is available on GitHub at: https://github.com/BasitAlawode/MR-PLIP

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