Breast Cancer Neoadjuvant Chemotherapy Treatment Response Prediction Using Aligned Longitudinal MRI and Clinical Data

• URL: http://arxiv.org/abs/2512.17759v1
• Date: Fri, 19 Dec 2025 16:32:31 GMT
• Title: Breast Cancer Neoadjuvant Chemotherapy Treatment Response Prediction Using Aligned Longitudinal MRI and Clinical Data
• Authors: Rahul Ravi, Ruizhe Li, Tarek Abdelfatah, Stephen Chan, Xin Chen,
• Abstract summary: The goal is to develop machine learning models to predict pathologic complete response (PCR binary classification) and 5-year relapse-free survival status (RFS binary classification)<n>The proposed framework includes tumour segmentation, image registration, feature extraction, and predictive modelling.<n>The proposed image registration-based feature extraction consistently improves the predictive models.
• Score: 6.850780131537867
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Aim: This study investigates treatment response prediction to neoadjuvant chemotherapy (NACT) in breast cancer patients, using longitudinal contrast-enhanced magnetic resonance images (CE-MRI) and clinical data. The goal is to develop machine learning (ML) models to predict pathologic complete response (PCR binary classification) and 5-year relapse-free survival status (RFS binary classification). Method: The proposed framework includes tumour segmentation, image registration, feature extraction, and predictive modelling. Using the image registration method, MRI image features can be extracted and compared from the original tumour site at different time points, therefore monitoring the intratumor changes during NACT process. Four feature extractors, including one radiomics and three deep learning-based (MedicalNet, Segformer3D, SAM-Med3D) were implemented and compared. In combination with three feature selection methods and four ML models, predictive models are built and compared. Results: The proposed image registration-based feature extraction consistently improves the predictive models. In the PCR and RFS classification tasks logistic regression model trained on radiomic features performed the best with an AUC of 0.88 and classification accuracy of 0.85 for PCR classification, and AUC of 0.78 and classification accuracy of 0.72 for RFS classification. Conclusions: It is evidenced that the image registration method has significantly improved performance in longitudinal feature learning in predicting PCR and RFS. The radiomics feature extractor is more effective than the pre-trained deep learning feature extractors, with higher performance and better interpretability.

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