Beyond Anatomy: Explainable ASD Classification from rs-fMRI via Functional Parcellation and Graph Attention Networks

• URL: http://arxiv.org/abs/2603.02518v1
• Date: Tue, 03 Mar 2026 02:05:20 GMT
• Title: Beyond Anatomy: Explainable ASD Classification from rs-fMRI via Functional Parcellation and Graph Attention Networks
• Authors: Syeda Hareem Madani, Noureen Bibi, Adam Rafiq Jeraj, Sumra Khan, Anas Zafar, Rizwan Qureshi,
• Abstract summary: Anatomical brain parcellations dominate rs-fMRI-based Autism Spectrum Disorder (ASD) classification.<n>We present a graph-based deep learning framework comparing anatomical (AAL) and functionally-derived (MSDL) parcellation strategies on the ABIDE I dataset.
• Score: 6.923757075165361
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Anatomical brain parcellations dominate rs-fMRI-based Autism Spectrum Disorder (ASD) classification, yet their rigid boundaries may fail to capture the idiosyncratic connectivity patterns that characterise ASD. We present a graph-based deep learning framework comparing anatomical (AAL, 116 ROIs) and functionally-derived (MSDL, 39 ROIs) parcellation strategies on the ABIDE I dataset. Our FSL preprocessing pipeline handles multi-site heterogeneity across 400 balanced subjects, with site-stratified 70/15/15 splits to prevent data leakage. Gaussian noise augmentation within training folds expands samples from 280 to 1,680. A three phase pipeline progresses from a baseline GCN with AAL (73.3% accuracy, AUC=0.74), to an optimised GCN with MSDL (84.0%, AUC=0.84), to a Graph Attention Network ensemble achieving 95.0% accuracy (AUC=0.98), outperforming all recent GNN-based benchmarks on ABIDE I. The 10.7-point gain from atlas substitution alone demonstrates that functional parcellation is the most impactful modelling decision. Gradient-based saliency and GNNExplainer analyses converge on the Posterior Cingulate Cortex and Precuneus as core Default Mode Network hubs, validating that model decisions reflect ASD neuropathology rather than acquisition artefacts. All code and datasets will be publicly released upon acceptance.

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