Quantum Spectroscopy with Undetected Photons for Biomolecular Sensing in the Mid-Infrared

• URL: http://arxiv.org/abs/2604.17704v1
• Date: Mon, 20 Apr 2026 01:35:09 GMT
• Title: Quantum Spectroscopy with Undetected Photons for Biomolecular Sensing in the Mid-Infrared
• Abstract summary: We investigate quantum spectroscopy with undetected photons for protein detection in the mid-infrared spectral region.<n>The simulated visibility spectra reproduce nearly identically the protein absorption features in the mid-IR and reveal temperature-induced changes to the protein secondary structure.
• Score: 33.72751145910978
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: We investigate quantum spectroscopy with undetected photons for protein detection in the mid-infrared spectral region. Classical Fourier-transform infrared spectroscopy of protein samples (bovine serum albumin and N-terminal pro-brain natriuretic peptide) is used as reference to define the sample's mid-infrared absorption, which is then embedded in a numerical model of a double-pass quantum interferometer. We analyse parameters that influence visibility of the interference pattern formed by the signal beams, including the length of nonlinear crystal, sample length and mirror-sample distance. This leads us to a practical quantum spectrometer design with optimal image contrast at the specific amide I-II spectral bands. The simulated visibility spectra reproduce nearly identically the protein absorption features in the mid-IR and reveal temperature-induced changes to the protein secondary structure. Overall, this provides practical design rules for future quantum bio-spectroscopy applications that use only visible wavelength sources and detectors.

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