$μ$GUIDE: a framework for quantitative imaging via generalized uncertainty-driven inference using deep learning

• URL: http://arxiv.org/abs/2312.17293v4
• Date: Wed, 4 Sep 2024 16:59:27 GMT
• Title: $μ$GUIDE: a framework for quantitative imaging via generalized uncertainty-driven inference using deep learning
• Authors: Maëliss Jallais, Marco Palombo,
• Abstract summary: $mu$GUIDE estimates posterior distributions of tissue microstructure parameters from any given biophysical model or MRI signal representation. The obtained posterior distributions allow to highlight degeneracies present in the model definition and quantify the uncertainty and ambiguity of the estimated parameters.
• Score: 0.0
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: This work proposes $\mu$GUIDE: a general Bayesian framework to estimate posterior distributions of tissue microstructure parameters from any given biophysical model or MRI signal representation, with exemplar demonstration in diffusion-weighted MRI. Harnessing a new deep learning architecture for automatic signal feature selection combined with simulation-based inference and efficient sampling of the posterior distributions, $\mu$GUIDE bypasses the high computational and time cost of conventional Bayesian approaches and does not rely on acquisition constraints to define model-specific summary statistics. The obtained posterior distributions allow to highlight degeneracies present in the model definition and quantify the uncertainty and ambiguity of the estimated parameters.

Related papers

• Diffusion models for probabilistic programming [56.47577824219207]
  Diffusion Model Variational Inference (DMVI) is a novel method for automated approximate inference in probabilistic programming languages (PPLs) DMVI is easy to implement, allows hassle-free inference in PPLs without the drawbacks of, e.g., variational inference using normalizing flows, and does not make any constraints on the underlying neural network model.
  arXiv  Detail & Related papers  (2023-11-01T12:17:05Z)
• Resolving quantitative MRI model degeneracy with machine learning via training data distribution design [2.2086005010186387]
  Quantitative MRI aims to map tissue properties non-invasively via models that relate unknown quantities to measured MRI signals. Estimating these unknowns, which has traditionally required model fitting, can now be done with one-shot machine learning (ML) approaches. Growing empirical evidence appears to suggest ML approaches remain susceptible to model degeneracy.
  arXiv  Detail & Related papers  (2023-03-09T18:10:45Z)
• Stable Deep MRI Reconstruction using Generative Priors [13.400444194036101]
  We propose a novel deep neural network based regularizer which is trained in a generative setting on reference magnitude images only. The results demonstrate competitive performance, on par with state-of-the-art end-to-end deep learning methods.
  arXiv  Detail & Related papers  (2022-10-25T08:34:29Z)
• NUQ: Nonparametric Uncertainty Quantification for Deterministic Neural Networks [151.03112356092575]
  We show the principled way to measure the uncertainty of predictions for a classifier based on Nadaraya-Watson's nonparametric estimate of the conditional label distribution. We demonstrate the strong performance of the method in uncertainty estimation tasks on a variety of real-world image datasets.
  arXiv  Detail & Related papers  (2022-02-07T12:30:45Z)
• Inverting brain grey matter models with likelihood-free inference: a tool for trustable cytoarchitecture measurements [62.997667081978825]
  characterisation of the brain grey matter cytoarchitecture with quantitative sensitivity to soma density and volume remains an unsolved challenge in dMRI. We propose a new forward model, specifically a new system of equations, requiring a few relatively sparse b-shells. We then apply modern tools from Bayesian analysis known as likelihood-free inference (LFI) to invert our proposed model.
  arXiv  Detail & Related papers  (2021-11-15T09:08:27Z)
• A deep learning based surrogate model for stochastic simulators [0.0]
  We propose a deep learning-based surrogate model for simulators. We utilize conditional maximum mean discrepancy (CMMD) as the loss-function. Results obtained indicate the excellent performance of the proposed approach.
  arXiv  Detail & Related papers  (2021-10-24T11:38:47Z)
• Information Theoretic Structured Generative Modeling [13.117829542251188]
  A novel generative model framework called the structured generative model (SGM) is proposed that makes straightforward optimization possible. The implementation employs a single neural network driven by an orthonormal input to a single white noise source adapted to learn an infinite Gaussian mixture model. Preliminary results show that SGM significantly improves MINE estimation in terms of data efficiency and variance, conventional and variational Gaussian mixture models, as well as for training adversarial networks.
  arXiv  Detail & Related papers  (2021-10-12T07:44:18Z)
• MINIMALIST: Mutual INformatIon Maximization for Amortized Likelihood Inference from Sampled Trajectories [61.3299263929289]
  Simulation-based inference enables learning the parameters of a model even when its likelihood cannot be computed in practice. One class of methods uses data simulated with different parameters to infer an amortized estimator for the likelihood-to-evidence ratio. We show that this approach can be formulated in terms of mutual information between model parameters and simulated data.
  arXiv  Detail & Related papers  (2021-06-03T12:59:16Z)
• Leveraging Global Parameters for Flow-based Neural Posterior Estimation [90.21090932619695]
  Inferring the parameters of a model based on experimental observations is central to the scientific method. A particularly challenging setting is when the model is strongly indeterminate, i.e., when distinct sets of parameters yield identical observations. We present a method for cracking such indeterminacy by exploiting additional information conveyed by an auxiliary set of observations sharing global parameters.
  arXiv  Detail & Related papers  (2021-02-12T12:23:13Z)
• Identification of Probability weighted ARX models with arbitrary domains [75.91002178647165]
  PieceWise Affine models guarantees universal approximation, local linearity and equivalence to other classes of hybrid system. In this work, we focus on the identification of PieceWise Auto Regressive with eXogenous input models with arbitrary regions (NPWARX) The architecture is conceived following the Mixture of Expert concept, developed within the machine learning field.
  arXiv  Detail & Related papers  (2020-09-29T12:50:33Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.