A Learnable Prior Improves Inverse Tumor Growth Modeling

• URL: http://arxiv.org/abs/2403.04500v2
• Date: Wed, 06 Nov 2024 11:05:27 GMT
• Title: A Learnable Prior Improves Inverse Tumor Growth Modeling
• Authors: Jonas Weidner, Ivan Ezhov, Michal Balcerak, Marie-Christin Metz, Sergey Litvinov, Sebastian Kaltenbach, Leonhard Feiner, Laurin Lux, Florian Kofler, Jana Lipkova, Jonas Latz, Daniel Rueckert, Bjoern Menze, Benedikt Wiestler,
• Abstract summary: We propose a novel framework that leverages the unique strengths of both approaches in a synergistic manner. We showcase the effectiveness of integrating a rapid deep-learning algorithm with a high-precision evolution strategy in estimating brain tumor cell concentrations from magnetic resonance images.
• Score: 8.87818392404259
• License:
• Abstract: Biophysical modeling, particularly involving partial differential equations (PDEs), offers significant potential for tailoring disease treatment protocols to individual patients. However, the inverse problem-solving aspect of these models presents a substantial challenge, either due to the high computational requirements of model-based approaches or the limited robustness of deep learning (DL) methods. We propose a novel framework that leverages the unique strengths of both approaches in a synergistic manner. Our method incorporates a DL ensemble for initial parameter estimation, facilitating efficient downstream evolutionary sampling initialized with this DL-based prior. We showcase the effectiveness of integrating a rapid deep-learning algorithm with a high-precision evolution strategy in estimating brain tumor cell concentrations from magnetic resonance images. The DL-Prior plays a pivotal role, significantly constraining the effective sampling-parameter space. This reduction results in a fivefold convergence acceleration and a Dice-score of 95%.

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