Related papers: Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trials

Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trials

URL: http://arxiv.org/abs/2409.04481v1
Date: Fri, 6 Sep 2024 02:03:38 GMT
Title: Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trials
Authors: Yizhen Zheng, Huan Yee Koh, Maddie Yang, Li Li, Lauren T. May, Geoffrey I. Webb, Shirui Pan, George Church,
Abstract summary: The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift. We investigate how these advanced computational models can uncover target-disease linkage, interpret complex biomedical data, enhance drug molecule design, predict drug efficacy and safety profiles, and facilitate clinical trial processes.
Score: 49.19897427783105
License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
Abstract: The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing clinical trial processes. This review highlights the expanding role of LLMs in revolutionizing various stages of the drug development pipeline. We investigate how these advanced computational models can uncover target-disease linkage, interpret complex biomedical data, enhance drug molecule design, predict drug efficacy and safety profiles, and facilitate clinical trial processes. Our paper aims to provide a comprehensive overview for researchers and practitioners in computational biology, pharmacology, and AI4Science by offering insights into the potential transformative impact of LLMs on drug discovery and development.

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