Graph Diffusion Network for Drug-Gene Prediction

• URL: http://arxiv.org/abs/2502.09335v1
• Date: Thu, 13 Feb 2025 13:54:58 GMT
• Title: Graph Diffusion Network for Drug-Gene Prediction
• Authors: Jiayang Wu, Wensheng Gan, Philip S. Yu,
• Abstract summary: We introduce a graph diffusion network for drug-gene prediction (GDNDGP) It employs meta-path-based homogeneous graph learning to capture drug-drug and gene-gene relationships. Second, it incorporates a parallel diffusion network that generates hard negative samples during training, eliminating the need for exhaustive negative sample retrieval.
• Score: 38.00034058447254
• License:
• Abstract: Predicting drug-gene associations is crucial for drug development and disease treatment. While graph neural networks (GNN) have shown effectiveness in this task, they face challenges with data sparsity and efficient contrastive learning implementation. We introduce a graph diffusion network for drug-gene prediction (GDNDGP), a framework that addresses these limitations through two key innovations. First, it employs meta-path-based homogeneous graph learning to capture drug-drug and gene-gene relationships, ensuring similar entities share embedding spaces. Second, it incorporates a parallel diffusion network that generates hard negative samples during training, eliminating the need for exhaustive negative sample retrieval. Our model achieves superior performance on the DGIdb 4.0 dataset and demonstrates strong generalization capability on tripartite drug-gene-disease networks. Results show significant improvements over existing methods in drug-gene prediction tasks, particularly in handling complex heterogeneous relationships. The source code is publicly available at https://github.com/csjywu1/GDNDGP.

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