A Topic Modeling Analysis of Stigma Dimensions, Social, and Related Behavioral Circumstances in Clinical Notes Among Patients with HIV

• URL: http://arxiv.org/abs/2506.09279v1
• Date: Tue, 10 Jun 2025 22:35:49 GMT
• Title: A Topic Modeling Analysis of Stigma Dimensions, Social, and Related Behavioral Circumstances in Clinical Notes Among Patients with HIV
• Authors: Ziyi Chen, Yiyang Liu, Mattia Prosperi, Krishna Vaddiparti, Robert L Cook, Jiang Bian, Yi Guo, Yonghui Wu,
• Abstract summary: We identified 9,140 cohort of people living with HIV (PLWHs) from the UF Health IDR.<n>We performed topic modeling analysis using Latent Dirichlet Allocation (LDA) to uncover stigma dimensions.<n>We conducted topic variation analysis among subgroups to examine differences across age and sex-specific demographics.
• Score: 21.478502613139582
• License: http://creativecommons.org/licenses/by-sa/4.0/
• Abstract: Objective: To characterize stigma dimensions, social, and related behavioral circumstances in people living with HIV (PLWHs) seeking care, using natural language processing methods applied to a large collection of electronic health record (EHR) clinical notes from a large integrated health system in the southeast United States. Methods: We identified 9,140 cohort of PLWHs from the UF Health IDR and performed topic modeling analysis using Latent Dirichlet Allocation (LDA) to uncover stigma dimensions, social, and related behavioral circumstances. Domain experts created a seed list of HIV-related stigma keywords, then applied a snowball strategy to iteratively review notes for additional terms until saturation was reached. To identify more target topics, we tested three keyword-based filtering strategies. Domain experts manually reviewed the detected topics using the prevalent terms and key discussion topics. Word frequency analysis was used to highlight the prevalent terms associated with each topic. In addition, we conducted topic variation analysis among subgroups to examine differences across age and sex-specific demographics. Results and Conclusion: Topic modeling on sentences containing at least one keyword uncovered a wide range of topic themes associated with HIV-related stigma, social, and related behaviors circumstances, including "Mental Health Concern and Stigma", "Social Support and Engagement", "Limited Healthcare Access and Severe Illness", "Treatment Refusal and Isolation" and so on. Topic variation analysis across age subgroups revealed differences. Extracting and understanding the HIV-related stigma dimensions, social, and related behavioral circumstances from EHR clinical notes enables scalable, time-efficient assessment, overcoming the limitations of traditional questionnaires and improving patient outcomes.

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