Leveraging AI to Accelerate Clinical Data Cleaning: A Comparative Study of AI-Assisted vs. Traditional Methods

• URL: http://arxiv.org/abs/2508.05519v1
• Date: Thu, 07 Aug 2025 15:49:32 GMT
• Title: Leveraging AI to Accelerate Clinical Data Cleaning: A Comparative Study of AI-Assisted vs. Traditional Methods
• Authors: Matthew Purri, Amit Patel, Erik Deurrell,
• Abstract summary: Octozi is an artificial intelligence-assisted platform that combines large language models with domain-specifics to transform clinical data review.<n>We demonstrate that AI assistance increased data cleaning throughput by 6.03-fold while simultaneously decreasing cleaning errors from 54.67% to 8.48%.<n>The system reduced false positive queries by 15.48-fold, minimizing unnecessary site burden.
• Score: 3.2666593942117688
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: Clinical trial data cleaning represents a critical bottleneck in drug development, with manual review processes struggling to manage exponentially increasing data volumes and complexity. This paper presents Octozi, an artificial intelligence-assisted platform that combines large language models with domain-specific heuristics to transform clinical data review. In a controlled experimental study with experienced clinical reviewers (n=10), we demonstrate that AI assistance increased data cleaning throughput by 6.03-fold while simultaneously decreasing cleaning errors from 54.67% to 8.48% (a 6.44-fold improvement). Crucially, the system reduced false positive queries by 15.48-fold, minimizing unnecessary site burden. These improvements were consistent across reviewers regardless of experience level, suggesting broad applicability. Our findings indicate that AI-assisted approaches can address fundamental inefficiencies in clinical trial operations, potentially accelerating drug development timelines and reducing costs while maintaining regulatory compliance. This work establishes a framework for integrating AI into safety-critical clinical workflows and demonstrates the transformative potential of human-AI collaboration in pharmaceutical clinical trials.

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