Cervical Optical Coherence Tomography Image Classification Based on
Contrastive Self-Supervised Texture Learning
- URL: http://arxiv.org/abs/2108.05081v1
- Date: Wed, 11 Aug 2021 07:52:59 GMT
- Title: Cervical Optical Coherence Tomography Image Classification Based on
Contrastive Self-Supervised Texture Learning
- Authors: Kaiyi Chen, Qingbin Wang, Yutao Ma
- Abstract summary: This study aims to develop a computer-aided diagnosis (CADx) approach to classifying in-vivo cervical OCT images based on self-supervised learning.
Besides high-level semantic features extracted by a convolutional neural network (CNN), the proposed CADx approach leverages unlabeled cervical OCT images' texture features learned by contrastive texture learning.
- Score: 2.674926127069043
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Background: Cervical cancer seriously affects the health of the female
reproductive system. Optical coherence tomography (OCT) emerges as a
non-invasive, high-resolution imaging technology for cervical disease
detection. However, OCT image annotation is knowledge-intensive and
time-consuming, which impedes the training process of deep-learning-based
classification models. Objective: This study aims to develop a computer-aided
diagnosis (CADx) approach to classifying in-vivo cervical OCT images based on
self-supervised learning. Methods: Besides high-level semantic features
extracted by a convolutional neural network (CNN), the proposed CADx approach
leverages unlabeled cervical OCT images' texture features learned by
contrastive texture learning. We conducted ten-fold cross-validation on the OCT
image dataset from a multi-center clinical study on 733 patients from China.
Results: In a binary classification task for detecting high-risk diseases,
including high-grade squamous intraepithelial lesion (HSIL) and cervical
cancer, our method achieved an area-under-the-curve (AUC) value of 0.9798 Plus
or Minus 0.0157 with a sensitivity of 91.17 Plus or Minus 4.99% and a
specificity of 93.96 Plus or Minus 4.72% for OCT image patches; also, it
outperformed two out of four medical experts on the test set. Furthermore, our
method achieved a 91.53% sensitivity and 97.37% specificity on an external
validation dataset containing 287 3D OCT volumes from 118 Chinese patients in a
new hospital using a cross-shaped threshold voting strategy. Conclusion: The
proposed contrastive-learning-based CADx method outperformed the end-to-end CNN
models and provided better interpretability based on texture features, which
holds great potential to be used in the clinical protocol of "see-and-treat."
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