Opportunistic Screening for Pancreatic Cancer using Computed Tomography Imaging and Radiology Reports

• URL: http://arxiv.org/abs/2504.00232v1
• Date: Mon, 31 Mar 2025 21:13:42 GMT
• Title: Opportunistic Screening for Pancreatic Cancer using Computed Tomography Imaging and Radiology Reports
• Authors: David Le, Ramon Correa-Medero, Amara Tariq, Bhavik Patel, Motoyo Yano, Imon Banerjee,
• Abstract summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with most cases diagnosed at stage IV and a five-year overall survival rate below 5%.<n>We developed and evaluated a deep learning fusion model that integrates radiology reports and CT imaging to predict PDAC risk.
• Score: 4.447609555191978
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with most cases diagnosed at stage IV and a five-year overall survival rate below 5%. Early detection and prognosis modeling are crucial for improving patient outcomes and guiding early intervention strategies. In this study, we developed and evaluated a deep learning fusion model that integrates radiology reports and CT imaging to predict PDAC risk. The model achieved a concordance index (C-index) of 0.6750 (95% CI: 0.6429, 0.7121) and 0.6435 (95% CI: 0.6055, 0.6789) on the internal and external dataset, respectively, for 5-year survival risk estimation. Kaplan-Meier analysis demonstrated significant separation (p<0.0001) between the low and high risk groups predicted by the fusion model. These findings highlight the potential of deep learning-based survival models in leveraging clinical and imaging data for pancreatic cancer.

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